典型文献
Value of Contrast-enhanced Ultrasound in Evaluating Synovitis and Predicting Recurrent Joint Bleeding of Hemophilia
文献摘要：
Objective:Contrast-enhanced ultrasound(CEUS)is advantageous for evaluating microcirculation,and has been applied to assess arthritis in previous studies.However,CEUS examinations have not been studied for hemophilia arthritis.Hemophilia arthritis is different from other arthritis,because it is induced by spontaneous joint bleeding.Hence,CEUS may have special value in evaluating hemophilia arthritis.The present study assessed the value of CEUS in evaluating synovial hypertrophy and predicting recurrent joint bleeding in severe hemophilia A patients.Methods:From August 2016 to January 2017,81 severe hemophilia A patients,who were referred to our hospital for ultrasound joint assessment with conventional ultrasound,were enrolled.Among these 81 patients,46 patients consented for CEUS examinations on the same day.Results:Compared to color Doppler flow imaging(CDFI),four more joints presented with a blood flow signal under CEUS mode.In addition,the synovial hypertrophy measured by CEUS was thicker than that measured by conventional ultrasound.The ultrasound scores(including the total grey-scale ultrasound score,joint effusion/hemarthrosis,synovial hypertrophy,CDFI semi-quantitative score,and CEUS semi-quantitative score)were significantly higher in the joint bleeding group than in the no joint bleeding group(P＜0.05).Furthermore,these ultrasound scores were positively correlated with the joint bleeding frequency,and had the highest correlation with the CEUS score(r=0.620,P＜0.05).Conclusion:CEUS can more accurately assess the degree of synovial hypertrophy and vascularization,and diagnose synovitis,when compared to conventional ultrasound.In addition,CEUS appears to be essential for evaluating the possibility of recurrent joint bleeding,and providing more reliable evidence for individualized treatment.
文献关键词：
中图分类号：
作者姓名：
Fei MA;Ya-ru ZHANG;Koon Hung LUKE;Hao LIU;Wan-xian LUO;Li ZHANG;Li-ling XIAO;Mei YI;Yang GAO;Wei-zhen WANG;Shi-qiu QIU;Xiao-qin FENG;Jing SUN;Ying-jia LI
作者机构：
Department of Medicine Ultrasonics,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;Hematology and Lab Medicine Divisions,Children Hospital of Eastern Ontario,Ottawa K1H 8L1,Canada;Department of Ultrasound,The Second People's Hospital of Shenzhen,Shenzhen 518025,China;Department of Hematology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;Department of Pediatrics,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China
文献出处：
引用格式：
[1]Fei MA;Ya-ru ZHANG;Koon Hung LUKE;Hao LIU;Wan-xian LUO;Li ZHANG;Li-ling XIAO;Mei YI;Yang GAO;Wei-zhen WANG;Shi-qiu QIU;Xiao-qin FENG;Jing SUN;Ying-jia LI-.Value of Contrast-enhanced Ultrasound in Evaluating Synovitis and Predicting Recurrent Joint Bleeding of Hemophilia)[J].当代医学科学(英文),2022(02):439-446
A类：
Synovitis,Hemophilia,consented,hemarthrosis
B类：
Value,Contrast,enhanced,Ultrasound,Evaluating,Predicting,Recurrent,Joint,Bleeding,Objective,ultrasound,CEUS,advantageous,evaluating,microcirculation,has,been,applied,arthritis,previous,studies,However,examinations,have,not,studied,hemophilia,different,from,other,because,induced,by,spontaneous,bleeding,Hence,may,special,value,study,assessed,synovial,hypertrophy,predicting,recurrent,severe,patients,Methods,From,August,January,who,were,referred,hospital,assessment,conventional,enrolled,Among,these,same,day,Results,Compared,color,Doppler,flow,imaging,CDFI,four,joints,presented,blood,signal,under,mode,In,addition,measured,was,thicker,than,that,scores,including,total,grey,scale,effusion,semi,quantitative,significantly,higher,group,Furthermore,positively,correlated,frequency,had,highest,correlation,Conclusion,accurately,degree,vascularization,diagnose,synovitis,when,compared,appears,essential,possibility,providing,reliable,evidence,individualized,treatment
AB值：
0.481326
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