典型文献
MiR-663a Inhibits Radiation-Induced Epithelium-to-Mesenchymal Transition by Targeting TGF-β1
文献摘要：
Objective miR-663a has been reported to be downregulated by X-ray irradiation and participates in radiation-induced bystander effect via TGF-β1. The goal of this study was to explore the role of miR-663a during radiation-induced Epithelium-to-mesenchymal transition (EMT). Methods TGF-β1 or IR was used to induce EMT. After miR-663a transfection, cell migration and cell morphological changes were detected and the expression levels of miR-663a, TGF-β1, and EMT-related factors were quantified. Results Enhancement of cell migration and promotion of mesenchymal changes induced by either TGF-β1 or radiation were suppressed by miR-663a. Furthermore, both X-ray and carbon ion irradiation resulted in the upregulation of TGF-β1 and downregulation of miR-663a, while the silencing of TGF-β1 by miR-663a reversed the EMT process after radiation. Conclusion Our findings demonstrate an EMT-suppressing effect by miR-663a via TGF-β1 in radiation-induced EMT.
文献关键词：
中图分类号：
作者姓名：
QU Pei;SHAO Zhi Ang;WANG Bing;HE Jin Peng;ZHANG Ya Nan;WEI Wen Jun;HUA Jun Rui;ZHOU Heng;LU Dong;DING Nan;WANG Ju Fang
作者机构：
Key Laboratory of Space Radiobiology of Gansu Province&Key Laboratory of Heavy Ion Radiation Biology and Medicine,Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000,Gansu,China;University of Chinese Academy of Sciences,Beijing 100049,China
文献出处：
引用格式：
[1]QU Pei;SHAO Zhi Ang;WANG Bing;HE Jin Peng;ZHANG Ya Nan;WEI Wen Jun;HUA Jun Rui;ZHOU Heng;LU Dong;DING Nan;WANG Ju Fang-.MiR-663a Inhibits Radiation-Induced Epithelium-to-Mesenchymal Transition by Targeting TGF-β1)[J].生物医学与环境科学（英文版）,2022(05):437-447
A类：
663a
B类：
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AB值：
0.488939
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