典型文献
Active DNA demethylation in plants:20 years of discovery and beyondFA
文献摘要：
Maintaining proper DNA methylation levels in the genome requires active demethylation of DNA. However, removing the methyl group from a modified cytosine is chemically difficult and therefore, the underlying mechanism of de-methylation had remained unclear for many years. The discovery of the first eukaryotic DNA demethylase, Arabidopsis thaliana REPRESSOR OF SILENCING 1 (ROS1), led to elucidation of the 5-methylcytosine base excision repair mechanism of active DNA demethylation. In the 20 years since ROS1 was discovered, our un-derstanding of this active DNA demethylation pathway, as well as its regulation and biological functions in plants, has greatly expanded. These exciting developments have laid the groundwork for further dissecting the regulatory mechanisms of active DNA demethylation, with potential ap-plications in epigenome editing to facilitate crop breeding and gene therapy.
文献关键词：
中图分类号：
作者姓名：
Heng Zhang;Zhizhong Gong;Jian-Kang Zhu
作者机构：
State Key Laboratory of Molecular Plant Genetics,Shanghai Centre for Plant Stress Biology,Centre for Excellence in Molecular Plant Sciences,Chinese Academy of Sciences,Shanghai 200032,China;State Key Laboratory of Plant Physiology and Biochemistry,College of Biological Sciences,China Agricultural University,Beijing 100193,China;School of Life Sciences,Institute of Life Science and Green Development,Hebei University,Baoding 071002,China;School of Life Sciences,Institute of Advanced Biotechnology,Southern University of Science and Technology,Shenzhen 518055,China
文献出处：
引用格式：
[1]Heng Zhang;Zhizhong Gong;Jian-Kang Zhu-.Active DNA demethylation in plants:20 years of discovery and beyondFA)[J].植物学报（英文版）,2022(12):2217-2239
A类：
beyondFA,REPRESSOR,SILENCING
B类：
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AB值：
0.608781
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
