典型文献
TDP-35, a truncated fragment of TDP-43, induces dose-dependent toxicity and apoptosis in flies
文献摘要：
TAR DNA-binding protein 43 (TDP-43) is an essential 414 amino acid protein that regulates multiple aspects of RNA biogenesis, processing, and transport. It localizes primarily in the nucleus, but abnormal translocation and accumulation in the cytosol occur under pathological conditions (Tziortzouda et al., 2021). TDP-43 abnormalities are typical pathological hallmarks of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. Mutations in the TDP-43-encoding gene TARDBP cause familial ALS, while wild-type TDP-43 is associated with almost all (～97％) of sporadic ALS cases and nearly half of frontotemporal lobar degeneration patients (～45％) (de Boer et al., 2020).
文献关键词：
中图分类号：
作者姓名：
Deepak Chhangani;Diego E.Rincon-Limas
作者机构：
Department of Neurology,McKnight Brain Institute,and Norman Fixel Institute for Neurological Diseases,University of Florida,Gainesville,FL,USA;Department of Neuroscience,Center for Translational Research in Neurodegenerative Disease,Genetics Institute,University of Florida,Gainesville,FL,USA
文献出处：
引用格式：
[1]Deepak Chhangani;Diego E.Rincon-Limas-.TDP-35, a truncated fragment of TDP-43, induces dose-dependent toxicity and apoptosis in flies)[J].中国神经再生研究（英文版）,2022(11):2441-2442
A类：
Tziortzouda
B类：
TDP,truncated,fragment,induces,dose,dependent,toxicity,apoptosis,flies,binding,protein,essential,amino,acid,that,regulates,multiple,aspects,biogenesis,processing,transport,It,localizes,primarily,nucleus,but,translocation,accumulation,cytosol,occur,under,pathological,conditions,et,abnormalities,are,typical,hallmarks,amyotrophic,lateral,sclerosis,ALS,frontotemporal,lobar,degeneration,Mutations,encoding,TARDBP,cause,familial,while,wild,type,associated,almost,sporadic,cases,nearly,half,patients,Boer
AB值：
0.661095
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