典型文献
Chemically oligomerizable TDP-43: a novel chemogenetic tool for studying the pathophysiology of amyotrophic lateral sclerosis
文献摘要：
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of both upper and lower motor neurons. Most ALS cases are sporadic, but approximately 5–10％ of patients have a familial background. To date, more than 30 familial ALS-causative genes have been identified (Maurel et al., 2018). The clinical manifestation and disease progression of sporadic ALS and familial ALS are similar and often clinically and pathologically indistinguishable, suggesting that they share a common pathophysiology in motor neuronal degeneration.
文献关键词：
中图分类号：
作者姓名：
Kohsuke Kanekura;Yoshiaki Yamanaka;Tamami Miyagi;Masahiko Kuroda
作者机构：
Department of Molecular Pathology,Tokyo Medical University,Tokyo,Japan
文献出处：
引用格式：
[1]Kohsuke Kanekura;Yoshiaki Yamanaka;Tamami Miyagi;Masahiko Kuroda-.Chemically oligomerizable TDP-43: a novel chemogenetic tool for studying the pathophysiology of amyotrophic lateral sclerosis)[J].中国神经再生研究（英文版）,2022(11):2434-2436
A类：
oligomerizable,Maurel
B类：
Chemically,TDP,novel,chemogenetic,tool,studying,pathophysiology,amyotrophic,lateral,sclerosis,Amyotrophic,ALS,devastating,neurodegenerative,disease,characterized,by,progressive,loss,both,upper,lower,motor,neurons,Most,cases,sporadic,but,approximately,patients,have,familial,background,To,date,more,than,causative,genes,been,identified,manifestation,progression,similar,often,clinically,pathologically,indistinguishable,suggesting,that,they,share,common,neuronal,degeneration
AB值：
0.670961
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