典型文献
K+/Cl-co-transporter-2 upmodulation:a multi-modal therapy to treat spinal cord injury
文献摘要：
Herein,the rationale and supporting evidence for the promise of developing K+/Cl-co-transporter-2 (KCC2) neuromodulatory therapies for spinal cord injury (SCl) is discussed.SCI is commonly a life-changing,unforeseen neurotrauma that has devastating consequences for the injured person,their families and society as a whole.Because less than 1％ of patients have a complete recovery,the vast majority of people after SCl have significant disabilities and can be entirely dependent upon others for assistance in their activities of daily living.The socioeconomic costs are a significant global burden,with SCI often occurring in adults during their peak earning years.Currently,there are no approved drugs that improve functional outcomes for people with SCI.Therefore,SCI commonly leads to a lifetime of disability,and new therapeutic approaches are urgently needed.
文献关键词：
中图分类号：
作者姓名：
Shane V.Hegarty;Joanna Stanicka
作者机构：
AXONIS Therapeutics,Inc.,LabCentral,Cambridge,MA,USA
文献出处：
引用格式：
[1]Shane V.Hegarty;Joanna Stanicka-.K+/Cl-co-transporter-2 upmodulation:a multi-modal therapy to treat spinal cord injury)[J].中国神经再生研究（英文版）,2022(09):1984-1986
A类：
upmodulation,neuromodulatory,SCl,neurotrauma
B类：
K+,transporter,multi,modal,therapy,treat,spinal,cord,injury,Herein,rationale,supporting,evidence,promise,developing,KCC2,therapies,discussed,SCI,commonly,changing,unforeseen,that,has,devastating,consequences,injured,person,their,families,society,whole,Because,less,than,patients,have,complete,recovery,majority,people,after,significant,disabilities,be,entirely,dependent,upon,others,assistance,activities,daily,living,socioeconomic,costs,are,global,burden,often,occurring,adults,during,peak,earning,years,Currently,there,approved,drugs,improve,functional,outcomes,Therefore,leads,lifetime,disability,new,therapeutic,approaches,urgently,needed
AB值：
0.648905
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
