Repetitive transcranial magnetic stimulation (rTMS) has been shown to effectively improve impaired swallowing in Parkinson's disease (PD) patients with dysphagia. However, little is known about how rTMS affects the corresponding brain regions in this patient group. In this case-control study, we examined data from 38 PD patients with dysphagia who received treatment at Beijing Rehabilitation Medicine Academy, Capital Medical University. The patients received high-frequency rTMS of the motor cortex once per day for 10 successive days. Changes in brain activation were compared via functional magnetic resonance imaging in PD patients with dysphagia and healthy controls. The results revealed that before treatment, PD patients with dysphagia showed greater activation in the precentral gyrus, supplementary motor area, and cerebellum compared with healthy controls, and this enhanced activation was weakened after treatment. Furthermore, before treatment, PD patients with dysphagia exhibited decreased activation in the parahippocampal gyrus, caudate nucleus, and left thalamus compared with healthy controls, and this activation increased after treatment. In addition, PD patients with dysphagia reported improved subjective swallowing sensations after rTMS. These findings suggest that swallowing function in PD patients with dysphagia improved after rTMS of the motor cortex. This may have been due to enhanced activation of the caudate nucleus and parahippocampal gyrus. The study protocol was approved by the Ethics Committee of Beijing Rehabilitation Hospital of Capital Medical University (approval No. 2018bkky017) on March 6, 2018 and was registered with Chinese Clinical Trial Registry (registration No. ChiCTR 1800017207) on July 18, 2018.

Pei-Ling Huang

Department of Neurological Rehabilitation,Beijing Rehabilitation Hospital of Capital Medical University,Beijing,China;Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application,School of Biomedical Engineering,Capital Medical University,Beijing,China;Department of NeurologicalRehabilitation,Beijing Rehabilitation Medicine Academy,Capital Medical University,Beijing,China

中国神经再生研究（英文版）

[1]Pei-Ling Huang-.Increased activation of the caudate nucleus and parahippocampal gyrus in Parkinson's disease patients with dysphagia after repetitive transcranial magnetic stimulation: a case-control study)[J].中国神经再生研究（英文版）,2022(05):1051-1058

precentral,2018bkky017

Increased,activation,caudate,nucleus,parahippocampal,gyrus,Parkinson,disease,patients,dysphagia,after,repetitive,transcranial,magnetic,stimulation,case,study,Repetitive,rTMS,has,been,shown,effectively,impaired,swallowing,However,little,known,about,affects,corresponding,brain,regions,this,group,examined,data,from,who,received,treatment,Beijing,Rehabilitation,Medicine,Academy,Capital,Medical,University,high,frequency,motor,cortex,once,per,successive,days,Changes,were,compared,via,functional,resonance,imaging,healthy,controls,results,revealed,that,before,showed,greater,supplementary,area,cerebellum,enhanced,was,weakened,Furthermore,exhibited,decreased,left,thalamus,increased,addition,reported,improved,subjective,sensations,These,findings,suggest,This,may,have,due,protocol,approved,by,Ethics,Committee,Hospital,approval,No,March,registered,Chinese,Clinical,Trial,Registry,registration,ChiCTR,July

0.47526