典型文献
Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain
文献摘要：
The role of neurotrophins in neuronal plasticity has recently become a strong focus inneuroregeneration research field to elucidate the biological mechanisms by which these molecules modulate synapses, modify the response to injury, and alter the adaptation response. Intriguingly, the prior studies highlight the role of p75 neurotrophin receptor (p75NTR) in various injuries and diseases such as central nervous system injuries, Alzheimer's disease and amyotrophic lateral sclerosis. More comprehensive elucidation of the mechanisms, and therapies targeting these molecular signaling networks may allow for neuronal tissue regeneration following an injury. Due to a diverse role of the p75NTR in biology, the body of evidence comprising its biological role is diffusely spread out over numerous fields. This review condenses the main evidence of p75NTR for clinical applications and presents new findings from published literature how data mining approach combined with bioinformatic analyses can be utilized to gain new hypotheses in a molecular and network level.
文献关键词：
中图分类号：
作者姓名：
Joel F.Ritala
作者机构：
Division of Clinical Neurosciences,Department of Neurosurgery,Turku University Hospital and University of Turku,Turku,Finland;Neurovascular Surgery Program,Section of Neurosurgery,The University of Chicago Medicine and Biological Sciences,Chicago,IL,USA;Department of Psychiatry,Central Hospital of Southern Ostrobothnia,Sein?joki,Finland;Neuroscience Center,HiLIFE,University of Helsinki,Helsinki,Finland
文献出处：
引用格式：
[1]Joel F.Ritala-.Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain)[J].中国神经再生研究（英文版）,2022(04):701-704
A类：
neurotrophins,inneuroregeneration
B类：
Towards,comprehensive,understanding,receptor,functions,interactions,brain,role,neuronal,plasticity,has,recently,become,strong,focus,research,elucidate,biological,mechanisms,by,which,molecules,modulate,synapses,modify,response,injury,alter,adaptation,Intriguingly,prior,studies,highlight,p75NTR,various,injuries,diseases,such,central,nervous,system,Alzheimer,amyotrophic,lateral,sclerosis,More,elucidation,therapies,targeting,molecular,signaling,networks,may,allow,tissue,following,Due,diverse,biology,body,evidence,comprising,its,diffusely,spread,out,over,numerous,fields,This,review,condenses,main,clinical,applications,presents,new,findings,from,published,literature,how,data,mining,approach,combined,bioinformatic,analyses,can,utilized,gain,hypotheses,level
AB值：
0.646931
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