INTRODUCTION Pulpal and periradicular pathosis, which can be caused by caries, trauma, or dental abnormalities, is a common disease in clinic for dental treatment. Root canal treatment (RCT) is a conventional option to manage the endodontic diseases in fully developed permanent teeth demonstrating outstanding clinical outcomes, while apexification procedure is the traditional treatment modality for the immature permanent teeth with pulp necrosis.1–2 The purpose of endodontic treatment is to eliminate pulp and periapical inflammation/infection and preserve the teeth. How-ever, these treatment procedures remove the pulp and some dentin tissues, which weaken the dentinal strength, immunologi-cal responses and proprioceptive functions, leading to a higher risk of reinfection and tooth fracture.3–4 How to reconstruct vital pulp and restore the biological function of teeth becomes the goal of contemporary endodontics.

Xi Wei;Maobin Yang;Lin Yue;Dingming Huang;Xuedong Zhou;Xiaoyan Wang;Qi Zhang;Lihong Qiu;Zhengwei Huang;Hanguo Wang;Liuyan Meng;Hong Li;Wenxia Chen;Xiaoying Zou;Junqi Ling

Department of Operative Dentistry and Endodontics,Hospital of Stomatology,Guanghua School of Stomatology,Sun Yat-Sen University&Guangdong Provincial Key Laboratory of Stomatology,Guangzhou,Guangdong,China;Department of Endodontology,Maurice H Kornberg School of Dentistry,Temple University,Philadelphia,Pennsylvania,USA;Department of Cariology and Endodontology,Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials,Beijing,China;State Key Laboratory of Oral Diseases&Department of Operative Dentistry and Endodontics,West China Hospital of Stomatology,National Center of Stomatology,National Clinical Research Centre for Oral Diseases,Sichuan University,Chengdu,China;Department of Endodontics,Stomatological Hospital and Dental School of Tongji University,Shanghai Engineering Research Center of Tooth Restoration and Regeneration,Shanghai,China;Department of Endodontics,School of Stomatology,China Medical University,Shenyang,Liaoning,China;Department of Endodontics,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,College of Stomatology,Shanghai Jiao Tong University,National Clinical Research Center for Oral Diseases,National Center for Stomatology,Shanghai Key Laboratory of Stomatology,Shanghai,China;Department of Operative Dentistry&Endodontics,School of Stomatology,The Fourth Military Medical University,Xi'an,China;The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education,School and Hospital of Stomatology,Wuhan University,Wuhan,China;Department of Endodontics,Beijing Stomatological Hospital,School of Stomatology,Capital Medical University,Beijing,China;College of Stomatology,Hospital of Stomatology,Guangxi Medical University,Nanning,Guangxi,China

国际口腔科学杂志（英文版）

[1]Xi Wei;Maobin Yang;Lin Yue;Dingming Huang;Xuedong Zhou;Xiaoyan Wang;Qi Zhang;Lihong Qiu;Zhengwei Huang;Hanguo Wang;Liuyan Meng;Hong Li;Wenxia Chen;Xiaoying Zou;Junqi Ling-.Expert consensus on regenerative endodontic procedures)[J].国际口腔科学杂志（英文版）,2022(04):411-423

Pulpal,periradicular,pathosis,apexification,dentinal,immunologi,endodontics

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