INTRODUCTION Osteoarthritis (OA) is a painful degenerative joint disease that troubles millions of human beings and causes a great financial burden worldwide.1 To date, no effective therapeutic strategies have been developed and current treatment options are merely limited to symptom relief or late-stage surgical intervention.2 As a site whose main function is to carry weight and is closely related to physical activities, articular cartilage is frequently subjected to various external forces, such as stresses, strains, and pressure.3 However, under some circumstances, aberrant mechanical stimu-lation is injuries to cartilage tissues, leading to cell apoptosis, extracellular matrix degradation and cartilage degeneration.4–7 Specifically, joint damage, such as anterior cruciate ligament rupture or loss of meniscus integrity, could affect joint stress distribution, consequently resulting in OA initiation and progres-sion.8 Therefore, aberrant mechanical force is a crucial factor for OA pathogenesis9 and investigation of the potential regulatory mechanism is greatly needed. Recently, an increasing number of studies have revealed the importance of epigenetics in regulating the formation and maintenance of joints.

Yu Jin;Zhen Liu;Zhenxia Li;Hairui Li;Cheng Zhu;Ruomei Li;Ting Zhou;Bing Fang

Department of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine;College of Stomatology, Shanghai Jiao Tong University;National Center for Stomatology;National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China

国际口腔科学杂志（英文版）

[1]Yu Jin;Zhen Liu;Zhenxia Li;Hairui Li;Cheng Zhu;Ruomei Li;Ting Zhou;Bing Fang-.Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1)[J].国际口腔科学杂志（英文版）,2022(03):396-409

Osteoarthritis,pathogenesis9

Histone,demethylase,JMJD3,downregulation,protects,against,aberrant,induced,osteoarthritis,through,control,NR4A1,INTRODUCTION,OA,painful,degenerative,disease,that,troubles,millions,human,beings,causes,financial,burden,worldwide,To,date,no,effective,therapeutic,strategies,have,been,developed,current,treatment,options,are,merely,limited,symptom,relief,stage,surgical,intervention,site,whose,function,carry,weight,closely,related,physical,activities,articular,cartilage,frequently,subjected,various,external,forces,such,stresses,strains,pressure,However,under,some,circumstances,mechanical,stimu,injuries,tissues,leading,apoptosis,extracellular,matrix,degradation,degeneration,Specifically,damage,anterior,cruciate,ligament,rupture,loss,meniscus,integrity,could,affect,distribution,consequently,resulting,initiation,progres,sion,Therefore,crucial,investigation,potential,regulatory,mechanism,greatly,needed,Recently,increasing,number,studies,revealed,importance,epigenetics,regulating,formation,maintenance,joints

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