典型文献
Iron-catalyzed hydroaminocarbonylation of alkynes:Selective and efficient synthesis of primary α,β-unsaturated amides
文献摘要：
α,β-Unsaturated primary amides are important intermediates and building blocks in organic synthesis.Herein,we report a ligand-free iron-catalyzed hydroaminocarbonylation of alkynes using NH4HCO3 as the ammonia source,enabling the highly efficient and regioselective synthesis of linear a,β-unsaturated primary amides.Various aromatic and aliphatic alkynes are transformed into the desired linear α,β-unsaturated primary amides in good to excellent yields.Further studies show that using NH4HCO3 as the ammonia source is key to obtain good yields and selectivity.The utility of this route is demonstrated with the synthesis of linear α,β-unsaturated amides including vanilloid receptor-1 antagonist TRPV-1.
文献关键词：
中图分类号：
作者姓名：
Zijun Huang;Jia Tang;Xiongwei Jiang;Tianle Xie;Minmin Zhang;Donghui Lan;Shaofeng Pi;Zhengde Tan;Bing Yi;Yuehui Li
作者机构：
Hunan Province Key Laboratory of Environmental Catalysis and Waste Rechemistry,College of Materials and Chemical Engineering,Hunan Institute of Engineering,Xiangtan 411104,China;State Key Laboratory for Oxo Synthesis and Selective Oxidation,Suzhou Research Institute of LI CP,Lanzhou Institute of Chemical Physics(LICP),Chinese Academy of Sciences,Lanzhou 730000,China
文献出处：
引用格式：
[1]Zijun Huang;Jia Tang;Xiongwei Jiang;Tianle Xie;Minmin Zhang;Donghui Lan;Shaofeng Pi;Zhengde Tan;Bing Yi;Yuehui Li-.Iron-catalyzed hydroaminocarbonylation of alkynes:Selective and efficient synthesis of primary α,β-unsaturated amides)[J].中国化学快报（英文版）,2022(11):4842-4845
A类：
hydroaminocarbonylation,Unsaturated
B类：
Iron,catalyzed,alkynes,Selective,efficient,synthesis,primary,unsaturated,amides,are,important,intermediates,building,blocks,organic,Herein,we,report,ligand,free,iron,using,NH4HCO3,as,ammonia,source,enabling,highly,regioselective,linear,Various,aromatic,aliphatic,transformed,into,desired,good,excellent,yields,Further,studies,show,that,key,obtain,selectivity,utility,this,route,demonstrated,including,vanilloid,receptor,antagonist,TRPV
AB值：
0.548364
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