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典型文献
Recent development in selective Tau tracers for PET imaging in the brain
文献摘要:
Abnormal Tau deposition is a crucial pathological hallmark of various neurodegenerative disorders de-fined as tauopathies,of which Alzheimer's disease is the most prominent one.To date,a large number of chemical entities with different structures have been developed as Tau imaging tracers for the early diag-nosis of tauopathies.Several of them with excellent bio-properties are currently being assessed in clinical trials,and more recently,the TauvidTM([18F]Flortaucipir,also known as[18F]AV1451 or[18F]T807)as the first Tau tracer was approved by the U.S.Food and Drug Administration in 2020.This review summarized the latest development of Tau tracers and analyzed their chemical structures,with particular attention to the effects of chemical structures on biological properties.In addition,we also discuss the limitations of current Tau imaging tracers,issues that need attention in the development of new tracers,and possible future directions.
文献关键词:
作者姓名:
Yuying Li;Tianqing Liu;Mengchao Cui
作者机构:
Key Laboratory of Radiopharmaceuticals,Ministry of Education,Beijing Normal University,Beijing 100875,China
引用格式:
[1]Yuying Li;Tianqing Liu;Mengchao Cui-.Recent development in selective Tau tracers for PET imaging in the brain)[J].中国化学快报(英文版),2022(07):3339-3348
A类:
tauopathies,TauvidTM,Flortaucipir,AV1451
B类:
Recent,development,selective,tracers,PET,imaging,brain,Abnormal,deposition,crucial,pathological,hallmark,various,neurodegenerative,disorders,fined,which,Alzheimer,disease,most,prominent,one,To,date,large,number,chemical,entities,different,structures,have,been,developed,early,diag,nosis,Several,them,excellent,properties,are,currently,being,assessed,clinical,trials,more,recently,18F,also,known,T807,first,was,approved,by,Food,Drug,Administration,This,review,summarized,latest,analyzed,their,particular,attention,effects,biological,In,addition,we,discuss,limitations,issues,that,need,new,possible,future,directions
AB值:
0.570638
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