典型文献
Old commercialized magnetic particles new trick:Intrinsic internal standard
文献摘要：
Magnetic particles(MPs)are the most widely used commercialized engineering particles,which gained great success in various biological applications.Inspired by their intrinsic Fe isotope composition,we dis-covered a commercialized MPs-internal standard's novel function to realize the accurate quantification of biomolecules.The bioassay of carcinoembryonic antigen(CEA)was chosen as a modal system.The Fe isotope in MPs and Au isotope in report probes were simultaneously and sensitively detected by the elemental mass spectrometry.197Au/57Fe isotopic ratios and CEA concentrations showed good linearity in the range of 0.6-300 ng/mL,with a detection limit of 0.09 ng/mL(3σ).The accuracy and precision of the proposed MPs-based immunoassay were greatly improved,by eliminating potential MPs loss dur-ing magnetic separation and absolute intensity fluctuations.Considering the exceptional availability and universality of commercialized MPs,the proposed method might open a new avenue for MPs'biological applications.
文献关键词：
中图分类号：
作者姓名：
Chaoqun Wang;Ziqiang Deng;Hu Zhang;Rui Liu;Yi Lv
作者机构：
Analytical&Testing Center,Sichuan University,Chengdu 610064,China;Key Laboratory of Green Chemistry and Technology of Ministry of Education,College of Chemistry,Sichuan University,Chengdu 610064,China;Department of Gastroenterology,West China Hospital,Sichuan University,Chengdu 610041,China
文献出处：
引用格式：
[1]Chaoqun Wang;Ziqiang Deng;Hu Zhang;Rui Liu;Yi Lv-.Old commercialized magnetic particles new trick:Intrinsic internal standard)[J].中国化学快报（英文版）,2022(03):1267-1270
A类：
197Au
B类：
Old,commercialized,magnetic,particles,new,trick,Intrinsic,internal,standard,Magnetic,MPs,are,most,widely,used,engineering,which,gained,success,various,biological,applications,Inspired,by,their,intrinsic,isotope,composition,dis,covered,novel,function,realize,accurate,quantification,biomolecules,bioassay,carcinoembryonic,antigen,CEA,was,chosen,modal,system,report,probes,were,simultaneously,sensitively,detected,elemental,mass,spectrometry,57Fe,isotopic,ratios,concentrations,showed,good,linearity,range,detection,limit,accuracy,precision,proposed,immunoassay,greatly,improved,eliminating,potential,loss,dur,separation,absolute,intensity,fluctuations,Considering,exceptional,availability,universality,method,might,open,avenue
AB值：
0.649125
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