典型文献
Meta-analysis with zero-event studies: a comparative study with application to COVID-19 data
文献摘要：
Background: Meta-analysis is a statistical method to synthesize evidence from a number of independent studies, including those from clinical studies with binary outcomes. In practice, when there are zero events in one or both groups, it may cause statistical problems in the subsequent analysis. Methods: In this paper, by considering the relative risk as the effect size, we conduct a comparative study that consists of four continuity correction methods and another state-of-the-art method without the continuity correction, namely the generalized linear mixed models (GLMMs). To further advance the literature, we also introduce a new method of the continuity correction for estimating the relative risk. Results: From the simulation studies, the new method performs well in terms of mean squared error when there are few studies. In contrast, the generalized linear mixed model performs the best when the number of studies is large. In addition, by reanalyzing recent coronavirus disease 2019 (COVID-19) data, it is evident that the double-zero-event studies impact the estimate of the mean effect size. Conclusions: We recommend the new method to handle the zero-event studies when there are few studies in a meta-analysis, or instead use the GLMM when the number of studies is large. The double-zero-event studies may be informative, and so we suggest not excluding them.
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作者姓名：
Jia-Jin Wei;En-Xuan Lin;Jian-Dong Shi;Ke Yang;Zong-Liang Hu;Xian-Tao Zeng;Tie-Jun Tong
作者机构：
Department of Mathematics,Hong Kong Baptist University,Hong Kong,China;Shenzhen Research Institute of Big Data,Shenzhen,China;College of Mathematics and Statistics,Shenzhen University,Shenzhen,China;Center for Evidence-Based and Translational Medicine,Zhongnan Hospital of Wuhan University,Wuhan,China
文献出处：
引用格式：
[1]Jia-Jin Wei;En-Xuan Lin;Jian-Dong Shi;Ke Yang;Zong-Liang Hu;Xian-Tao Zeng;Tie-Jun Tong-.Meta-analysis with zero-event studies: a comparative study with application to COVID-19 data)[J].军事医学研究（英文）,2022(01):126-137
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AB值：
0.492895
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