典型文献
Proteomic characterization of four subtypes of M2 macrophages derived from human THP-1 cells
文献摘要：
Macrophages are widely distributed immune cells that contribute to tissue homeostasis. Human THP-1 cells have been widely used in various macrophage-associated studies, especially those involving pro-inflammatory M1 and anti-inflammatory M2 phenotypes. However, the molecular characterization of four M2 subtypes (M2a, M2b, M2c, and M2d) derived from THP-1 has not been fully investigated. In this study, we systematically analyzed the protein expression profiles of human THP-1-derived macrophages (M0, M1, M2a, M2b, M2c, and M2d) using quantitative proteomics approaches. The commonly and specially regulated proteins of the four M2 subtypes and their potential biological functions were further investigated. The results showed that M2a and M2b, and M2c and M2d have very similar protein expression profiles. These data could serve as an important resource for studies of macrophages using THP-1 cells, and provide a reference to distinguish different M2 subtypes in macrophage-associated diseases for subsequent clinical research.
文献关键词：
中图分类号：
作者姓名：
Pengfei LI;Chen MA;Jing LI;Shanshan YOU;Liuyi DANG;Jingyu WU;Zhifang HAO;Jun LI;Yuan ZHI;Lin CHEN;Shisheng SUN
作者机构：
College of Life Science,Northwest University,Xi'an 710069,China
引用格式：
[1]Pengfei LI;Chen MA;Jing LI;Shanshan YOU;Liuyi DANG;Jingyu WU;Zhifang HAO;Jun LI;Yuan ZHI;Lin CHEN;Shisheng SUN-.Proteomic characterization of four subtypes of M2 macrophages derived from human THP-1 cells)[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2022(05):407-422
A类：
M2b,M2c,M2d
B类：
Proteomic,characterization,four,subtypes,macrophages,derived,from,human,THP,cells,Macrophages,are,widely,distributed,immune,that,contribute,tissue,homeostasis,Human,have,been,used,various,associated,studies,especially,those,involving,inflammatory,M1,phenotypes,However,molecular,M2a,has,fully,investigated,In,this,study,systematically,analyzed,expression,profiles,M0,using,quantitative,proteomics,approaches,commonly,regulated,proteins,their,potential,biological,functions,were,further,results,showed,very,similar,These,data,could,serve,important,resource,provide,reference,distinguish,different,diseases,subsequent,clinical,research
AB值：
0.487735
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