典型文献
Box-Behnken experimental design for optimizing process parameters in carbonate-promoted direct thiophene carboxylation reaction with carbon dioxide
文献摘要：
A feasible synthesis route is developed for achieving the direct carboxylation of thiophene and CO2 in a relatively mild solvent-free carboxylate-assisted carbonate(semi)molten state.The effects of reaction factors on the carboxylate yield are investigated in the preliminary screening experiments,and the phase behavior analysis of the reaction medium is detected through the thermal characterization analysis of in-situ high temperature X-ray diffraction measurement(in-situ XRD).The application of response surface methodology(RSM)based on the Box-Behnken design(BBD)is conducted to investigate the effect of the reaction parameters,such as reaction temperature,carbonate proportion,CO2 pressure and thiophene amount,on the product yield.The regressed second-order polynomial model equation well correlates all the independent variables.The analysis of variance(ANOVA)results reveal that the quadratic effect of reaction temperature is the most effective parameter in this carboxylation reaction owing to it's the high-est contribution to the sum of square(30.18％).The optimum reaction conditions for maximum product yield are the reaction temperature of 287℃,carbonate proportion of 32.20％,CO2 pressure of 1.0MPa and thiophene amount of 9.35 mmol.Operating under these selected experimental conditions,a high product yield(50.98％)can be achieved.
文献关键词：
中图分类号：
作者姓名：
Qingjun Zhang;Youguang Ma;Xigang Yuan;Aiwu Zeng
作者机构：
State Key Laboratory of Chemical Engineering,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300350,China;Chemical Engineering Research Center,Collaborative Innovative Center of Chemical Science and Engineering(Tianjin),Tianjin 300350,China
文献出处：
引用格式：
[1]Qingjun Zhang;Youguang Ma;Xigang Yuan;Aiwu Zeng-.Box-Behnken experimental design for optimizing process parameters in carbonate-promoted direct thiophene carboxylation reaction with carbon dioxide)[J].中国化学工程学报（英文版）,2022(10):222-234
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B类：
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AB值：
0.537335
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