首站-论文投稿智能助手
典型文献
细胞色素P450 2D6基因多态性与美托洛尔和普罗帕酮联用的安全性
文献摘要:
美托洛尔和普罗帕酮是心血管疾病常用药物。2药均通过肝脏细胞色素P450(CYP)2D6代谢,但普罗帕酮不仅是CYP2D6底物,也是CYP2D6抑制剂,与美托洛尔联用可能发生相互作用,导致不良反应发生。这种相互作用也取决于CYP2D6基因型。对于CYP2D6基因表型为慢代谢型(PM)和中间代谢型(IM)的患者,美托洛尔和普罗帕酮联用时可因普罗帕酮对CYP2D6的抑制而导致美托洛尔血药浓度升高。因此,应尽量避免美托洛尔与普罗帕酮联用。对于需要2药联合治疗的患者,用药期间应注意监测患者血压、心率、心电图变化,有条件者应检测CYP2D6基因型并根据检测结果调整药物剂量。
文献关键词:
美托洛尔;普罗帕酮;药物相互作用;基因;细胞色素P450 CYP2D6;药物相关副作用和不良反应
作者姓名:
李雪;张青霞;尹春琳
作者机构:
首都医科大学宣武医院心脏内科,国家老年疾病临床医学研究中心,北京 100053;首都医科大学宣武医院药学部,国家老年疾病临床医学研究中心,北京 100053
引用格式:
[1]李雪;张青霞;尹春琳-.细胞色素P450 2D6基因多态性与美托洛尔和普罗帕酮联用的安全性)[J].药物不良反应杂志,2022(07):365-370
A类:
药物相关副作用和不良反应
B类:
细胞色素,P450,基因多态性,美托洛尔,和普罗,普罗帕酮,心血管疾病,常用药物,肝脏细胞,CYP2D6,底物,不良反应发生,基因型,基因表型,慢代谢型,PM,中间代谢型,IM,可因,血药浓度,尽量避免,联合治疗,心电图,条件者,药物剂量,药物相互作用
AB值:
0.247813
相似文献
神经精神药理学治疗药物监测共识指南:2017版
C.Hiemke;N.Bergemann;H.W.Clement;A.Conca;J.Deckert;K.Domschke;G.Eckermann;K.Egberts;M.Gerlach;C.Greiner;G.Gründer;E.Haen;U.Havemann-Reinecke;G.Hefner;R.Helmer;G.Janssen;E-.Jaquenoud;G.Laux;T.Messer;R.M?ssner;M.J.Müller;M.Paulzen;B.Pfuhlmann;P.Riederer;A.Saria;B.Schoppek;G.Schoretsanitis;M.Schwarz;M.Silva Gracia;B.Stegmann;W.Steimer;J.C.Stingl;M.Uhr;S.Ulrich;S.Unterecker;R.Waschgler;G.Zernig;G.Zurek;P.Baumann;李文标;果伟;贺静;鲍爽;路钊;牛梦溪;阮灿军;臧彦楠;王勇;张玲;刘辰庚;李洁-Department of Psychiatry and Psychotherapy,University Medical Center of Mainz,Mainz,Germany;Institute of Clinical Chemistry and Laboratory Medicine,University Medical Center of Mainz,Mainz,Germany;Kitzberg Hospitals,Center for Psychosomatic Medicine and Psychotherapy,Bad Mergentheim,Germany;Department of Child and Adolescent Psychiatry,University of Freiburg,Freiburg,Germany;Servizio Psichiatrico del Comprensorio Sanitario di Bolzano,Bolzano,Italy;Department of Psychiatry,Psychotherapy and Psychosomatics,University Hospital of Würzburg,Germany;Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg,Freiburg,Germany;Psychiatric Hospital,Kaufbeuren,Germany;Department of Child and Adolescent Psychiatry,Psychosomatics and Psychotherapy,Center of Mental Health,University Hospi-tal of Würzburg,Germany;Federal Institute for Drugs and Medical Devices (BfArM),Bonn,Germany;Department of Psychiatry,Psychotherapy and Psychosomatics,RWTH Aachen University,Aachen,and JARA–Translational Brain Medicine,Aachen,Germany;Clinical Pharmacology,Department of Psychiatry and Psychotherapy and Department of Pharmacology and Toxicology,Uni-versity of Regensburg,Regensburg,Germany;Department of Psychiatry and Psychosomatics,University of G?ttingen,G?ttingen,Germany;Psychiatric Hospital,Vitos Klinik,Eichberg,Eltville,Germany;Center of Epilepsy,Bielefeld,Germany;Medical Laboratory Stein,Limbach Group,M?nchengladbach,Germany;Psychiatric Hospital,K?nigsfelden,Brugg,Aargau,Switzerland;Institute of Psychological Medicine,Haag in Oberbayern,Germany;Danuviuskliniken,Psychiatric Hospital,Pfaffenhofen,Germany;Department of Psychiatry and Psychotherapy,University of Tübingen,Tübingen,Germany;Psychiatric Hospitals Oberberggruppe,Berlin,Germany;Psychiatric Hospital Weisser Hirsch,Dresden,Germany;Experimental Psychiatry Unit,Department of Psychiatry1,Medical University of Innsbruck,Innsbruck,Austria;kbo-Isar-Amper Klinikum München-Ost,Psychiatric Hospital,Munich-Haar,Germany;Department of Psychiatry,University of Bern,Bern,Switzerland;Department of Laboratory Medicine,Ludwig Maximilian University,Munich,Germany;Institute of Clinical Chemistry and Pathobiochemistry,Technical University Munich,Munich,Germany;Max Planck Institute of Psychiatry,Munich,Germany;Aristo Pharma GmbH,Berlin,Germany;Psychiatric Hospital,Feldkirch,Austria;Private Practice for Psychotherapy and Court-Certified Witness,Hall in Tirol,Austria;Medical Laboratory Bremen,Bremen,Germany;Department of Psychiatry,University of Lausanne,Prilly-Lausanne,Switzerland;中国 北京 首都医科大学附属北京安定医院,国家精神心理疾病临床医学研究中心,精神疾病诊断与治疗北京重点实验室;中国 天津 天津市安定医院
机标中图分类号,由域田数据科技根据网络公开资料自动分析生成,仅供学习研究参考。