典型文献
Chinese Medicine Regulates DNA Methylation to Treat Haematological Malignancies:A New Paradigm of"State-Target Medicine"
文献摘要：
Aberrant regulation of DNA methylation plays a crucial causative role in haematological malignancies(HMs).Targeted therapy,aiming for DNA methylation,is an effective mainstay of modem medicine;however,many issues remain to be addressed.The progress of epigenetic studies and the proposed theory of"state-target medicine"have provided conditions to form a new treatment paradigm that combines the"body state adjustment"of CM with targeted therapy.We discussed the correlation between Chinese medicine(CM)syndromes/states and DNA methylation in this paper.Additionally,the latest research findings on the intervention and regulation of DNA methylation in HMs,including the core targets,therapy status,CM compounds and active components of the Chinese materia medica were concisely summarized to establish a theoretical foundation of"state-target synchronous conditioning"pattern of integrative medicine for HMs,simultaneously leading a new perspective in clinical diagnosis and therapy.
文献关键词：
中图分类号：
作者姓名：
SHEN Feng-lin;ZHAO Yan-na;YU Xiao-ling;WANG Bo-lin;WU Xiao-long;LAN Gao-chen;GAO Rui-Ian
作者机构：
Institute of Hematology Research,the First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou(310006),China
文献出处：
引用格式：
[1]SHEN Feng-lin;ZHAO Yan-na;YU Xiao-ling;WANG Bo-lin;WU Xiao-long;LAN Gao-chen;GAO Rui-Ian-.Chinese Medicine Regulates DNA Methylation to Treat Haematological Malignancies:A New Paradigm of"State-Target Medicine")[J].中国结合医学杂志（英文版）,2022(06):560-566
A类：
Regulates,Haematological,Malignancies,haematological
B类：
Chinese,Medicine,Methylation,Treat,New,Paradigm,State,Aberrant,regulation,methylation,plays,crucial,causative,role,malignancies,HMs,Targeted,therapy,aiming,effective,mainstay,modem,medicine,however,many,issues,remain,addressed,progress,epigenetic,studies,proposed,theory,have,provided,conditions,form,new,treatment,paradigm,that,combines,body,adjustment,CM,targeted,We,discussed,correlation,between,syndromes,states,this,paper,Additionally,latest,research,findings,intervention,including,core,targets,status,compounds,active,components,materia,medica,were,concisely,summarized,establish,theoretical,foundation,synchronous,conditioning,pattern,integrative,simultaneously,leading,perspective,clinical,diagnosis
AB值：
0.631125
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