Objective:To observe the influence of acupuncture on microcirculation perfusion of the pericardium meridian and heart in acute myocardial ischemia (AMI) rats and evaluate whether acupuncture can simultaneously affect the meridians and corresponding viscera.Additionally,acupoints at different meridians were compared and whether they exert the same effects was discussed.Methods:Totally 32 Sprague-Dawley rats were subjected to left anterior descending (LAD) ligation to develop an AMI model.Rats were divided into 4 groups,including AMI,acupuncture Neiguan (PC 6),Lieque (LU 7) and Qiansanli(LI 10) groups (n=8).Eight rats received only thoracotomy (sham-operated group).The rats in the acupuncture groups received manual acupuncture at PC 6,LU 7 and LI 10 acupoints for 15 min,respectively.The microcirculation perfusion of pericardium meridian and heart was monitored by laser speckle peffusion imager(LSPI) before,during and after acupuncture manipulation for 15 min.Subsequently,the perfusion unit (PU)was calculated and analyzed by PSI System.Results:After LAD,compared to pre-acupuncture stage,the heart microcirculation perfusion (HMP) in the AMI group decreased continuously at during-acupuncture (P＞0.05) and post-acupuncture stages (P＜0.05),and the pericardium meridian microcirculation perfusion (PMP) showed no significant differences at 3 stages (P＞0.05).Compared to pre-acupuncture stage,the PMP and HMP in PC 6 group significantly increased during acupuncture manipulation (both P＜0.05),and PMP decreased obviously after acupuncture (P＜0.05).The PMP in the LU 7 and LI 10 groups were slightly elevated (both P＞0.05);however,they were significantly reduced after acupuncture manipulation (both P＜0.05).Additionally,HMP of LI 10 group was decreased significantly during acupuncture,especially compared to pre-acupuncture stage(P＜0.05).Conclusions:Acupuncture at PC 6 obviously increased the PMP and HMP in AMI rats,and the effects were superior to at LU 7 and LI 10 acupoints.It was further confirmed that acupuncture promoted qi and blood circulation,indicating that acupoint specificity exists and features a meridian-propagated effect.

ZHUANG Yi;ZHOU Jie;ZHOU Yu-mei;CHEN Jiao;WU Ping;LYU Pei-ran;WAN Min;LUO Liao-jun;CAI Ding-jun;LIANG Fan-rong

College of Acupuncture,Moxibustion and Tuina,Chengdu University of Traditional Chinese Medicine,Chengdu 610075 ,China;College of Acupuncture,Moxibustion and Tuina,Nanjing University of Chinese Medicine,Nanjing 210023 ,China;Department of Acupuncture and Moxibustion,Xin Du Hospital of Traditional Chinese Medicine,Chengdu 610599 ,China;The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen,Guangdong Province 518005 ,China

中国结合医学杂志（英文版）

[1]ZHUANG Yi;ZHOU Jie;ZHOU Yu-mei;CHEN Jiao;WU Ping;LYU Pei-ran;WAN Min;LUO Liao-jun;CAI Ding-jun;LIANG Fan-rong-.Influence of Acupuncture on Microcirculation Perfusion of Pericardium Meridian and Heart in Acute Myocardial Ischemia Model Rats)[J].中国结合医学杂志（英文版）,2022(01):69-75

Microcirculation,Pericardium,Neiguan,Lieque,Qiansanli,peffusion,LSPI

Influence,Acupuncture,Perfusion,Meridian,Heart,Acute,Myocardial,Ischemia,Model,Rats,Objective,observe,influence,acupuncture,microcirculation,perfusion,pericardium,heart,acute,myocardial,ischemia,AMI,rats,evaluate,whether,simultaneously,affect,meridians,corresponding,viscera,Additionally,acupoints,different,were,compared,they,exert,same,effects,was,discussed,Methods,Totally,Sprague,Dawley,subjected,left,anterior,descending,LAD,ligation,develop,model,divided,into,groups,including,LU,LI,Eight,received,only,thoracotomy,sham,operated,manual,respectively,monitored,by,laser,speckle,imager,before,during,after,manipulation,Subsequently,unit,PU,calculated,analyzed,PSI,System,Results,After,pre,HMP,decreased,continuously,post,stages,PMP,showed,no,differences,Compared,significantly,increased,both,obviously,slightly,elevated,however,reduced,especially,Conclusions,superior,It,further,confirmed,that,promoted,qi,blood,indicating,specificity,exists,features,propagated

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