Harmine is a β-carboline alkaloid isolated from Banisteria caapi and Peganum harmala L with various pharmacological activities,including antioxidant,anti-inflammatory,antitumor,anti-depressant,and anti-leishmanial capabilities.Nevertheless,the pharmacological effect of harmine on cardiomyocytes and heart muscle has not been reported.Here we found a protective effect of harmine on cardiac hypertrophy in spontaneously hypertensive rats in vivo.Further,harmine could inhibit the phenotypes of norepinephrine-induced hypertrophy in human embryonic stem cell-derived cardiomyocytes in vitro.It reduced the enlarged cell surface area,reversed the increased calcium handling and contractility,and downregulated expression of hypertrophy-related genes in norepinephrine-induced hypertrophy of human cardiomyocytes derived from embryonic stem cells.We further showed that one of the potential underlying mechanism by which harmine alleviates cardiac hypertrophy relied on inhibition of NF-KB phosphorylation and the stimulated inflammatory cytokines in pathological ventricular remodeling.Our data suggest that harmine is a promising therapeutic agent for cardiac hypertrophy independent of blood pressure modulation and could be a promising addition of current medications for cardiac hypertrophy.

Jie Huang;Yang Liu;Jia-xin Chen;Xin-ya Lu;Wen-jia Zhu;Le Qin;Zi-xuan Xun;Qiu-yi Zheng;Er-min Li;Ning Sun;Chen Xu;Hai-yan Chen

Department of Physiology and Pathophysiology,State Key Laboratory of Medical Neurobiology,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China;Department of Echocardiography,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Shanghai Key Lab of Birth Defect,Children's Hospital of Fudan University,Shanghai 201100,China;Research Center on Aging and Medicine,Fudan University,Shanghai 200032,China

中国药理学报（英文版）

[1]Jie Huang;Yang Liu;Jia-xin Chen;Xin-ya Lu;Wen-jia Zhu;Le Qin;Zi-xuan Xun;Qiu-yi Zheng;Er-min Li;Ning Sun;Chen Xu;Hai-yan Chen-.Harmine is an effective therapeutic small molecule for the treatment of cardiac hypertrophy)[J].中国药理学报（英文版）,2022(01):50-63

Harmine,Banisteria,caapi,Peganum,leishmanial

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