The development of organ-on-a-chip systems demands high requirements for adequate micro-pump performance,which needs excellent performance and effective transport of active cells.In this study,we designed a piezoelectric pump with a flexible venous valve inspired by that of humans.Performance test of the proposed pump with deionized water as the transmission medium shows a maximum output flow rate of 14.95 mL/min when the input voltage is 100 V,and the pump can transfer aqueous solutions of glycerol with a viscosity of 10.8 mPa·s.Cell survival rate can reach 97.22％with a yeast cell culture solution as the transmission medium.A computational model of the electric-solid-liquid multi-physical field coupling of the piezoelectric pump with a flexible venous valve is established,and simulation results are consistent with experimental results.The proposed pump can help to construct the circulating organ-on-a-chip system,and the simple structure and portable application can enrich the design of microfluidic systems.In addition,the multi-physical field coupling computational model established for the proposed piezoelectric pump can provide an in-depth study of the characteristics of the flow field,facilitating the optimal design of the micro-pump and providing a reference for the further study of active cell transport in organ-on-a-chip systems.

Jun HUANG;Jiaming LIU;Kai LI;Lei ZHANG;Quan ZHANG;Yuan WANG

Research Center of Fluid Machinery Engineering and Technology,Jiangsu University,Zhenjiang 212013,China;Research and Development Center of New Combined Power,Shaanxi Province Aerospace and Astronautics Propulsion Research Institute Co.,Ltd.,Xi'an 710076,China;School of Food and Biological Engineering,Jiangsu University,Zhenjiang 212013,China;School of Mechatronic Engineering and Automation,Shanghai University,Shanghai 200072,China;College of Communication Engineering,Army Engineering University of PLA,Nanjing 210007,China

机械工程前沿

[1]Jun HUANG;Jiaming LIU;Kai LI;Lei ZHANG;Quan ZHANG;Yuan WANG-.Piezoelectric pump with flexible venous valves for active cell transmission)[J].机械工程前沿,2022(04):127-139

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