典型文献
Seroprevalence of neutralizing antibodies against adenovirus type 26 and 35 in healthy populations from Guangdong and Shandong provinces,China
文献摘要：
Human adenoviruses type 26(HAdV26)and type 35(HAdV35)have increasingly become the choice of adenovirus vectors for vaccine application.However,the population pre-existing immunity to these two adenoviruses in China,which may reduce vaccine efficacy,remains largely unknown.Here,we established micro-neutralizing(MN)assays to investigate the seroprevalence of neutralizing antibodies(nAbs)against HAdV26 and HAdV35 in the general population of Guangdong and Shandong provinces,China.A total of 1184 serum samples were collected,47.0％and 15.8％of which showed HAdV26 and HAdV35 nAb activity,respectively.HAdV26-seropositive individuals tended to have more moderate nAbs titers(201-1000),while HAdV35-seropositive individuals appeared to have more low nAbs titers(72-200).The seropositive rates of HAdV26 and HAdV35 in individuals younger than 20 years old were very low.The seropositive rates of HAdV26 increased with age before 70 years old and decreased thereafter,while HAdV35 seropositive rates did not show similar characteristics.Notably,the seropositive rates and nAb levels of both HAdV26 and HAdV35 were higher in Guangdong Province than in Shandong Province,but did not exert significant differences between males and females.The seroprevalence between HAdV26 and HAdV35 showed little correlation,and no significant cross-neutralizing activity was detected.These results clarified the characteristics of the herd immunity against HAdV26 and HAdV35,and provided information for the rational development and application of HAdV26 and HAdV35 as vaccine vectors in China.
文献关键词：
中图分类号：
作者姓名：
Haisu Yi;Qian Wang;Jiankai Deng;Hengchun Li;Yingkun Zhang;Zhilong Chen;Tianxin Ji;Wenming Liu;Xuehua Zheng;Qinghua Ma;Xinxin Sun;Yudi Zhang;Xuegao Yu;Mengzhang He;Ling Chen;Ying Feng
作者机构：
State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou,510120,China;Department of Laboratory Medicine,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,510080,China;Center for Infection and Immunity,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou,510530,China;University of Chinese Academy of Science,Beijing,100049,China;Clinical Laboratory,Pingyi Hospital of Chinese Medicine,Linyi,273399,China;Xiamen Institutes of Respiratory Health,Xiamen,361013,China;Department of Respiratory and Critical Care Medicine,The Second Affiliated Hospital of Guangzhou Medical University,Guangzhou,510260,China;Guangzhou Laboratory&Bioland Laboratory,Guangzhou,510320,China
文献出处：
引用格式：
[1]Haisu Yi;Qian Wang;Jiankai Deng;Hengchun Li;Yingkun Zhang;Zhilong Chen;Tianxin Ji;Wenming Liu;Xuehua Zheng;Qinghua Ma;Xinxin Sun;Yudi Zhang;Xuegao Yu;Mengzhang He;Ling Chen;Ying Feng-.Seroprevalence of neutralizing antibodies against adenovirus type 26 and 35 in healthy populations from Guangdong and Shandong provinces,China)[J].中国病毒学,2022(05):716-723
A类：
adenoviruses,HAdV26,HAdV35,seroprevalence,nAbs
B类：
Seroprevalence,neutralizing,antibodies,against,type,healthy,populations,from,Guangdong,Shandong,provinces,China,Human,have,increasingly,become,choice,vectors,vaccine,application,However,existing,immunity,these,two,which,may,reduce,efficacy,remains,largely,unknown,Here,established,micro,MN,assays,investigate,general,total,serum,samples,were,collected,showed,activity,respectively,seropositive,individuals,tended,more,moderate,titers,while,appeared,low,rates,younger,than,years,old,very,increased,age,before,decreased,thereafter,did,not,similar,characteristics,Notably,levels,both,higher,Province,but,exert,significant,differences,between,females,little,correlation,cross,was,detected,These,results,clarified,herd,provided,information,rational,development
AB值：
0.386191
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