典型文献
Growth hormone attenuates the brain damage caused by ZIKV infection in mice
文献摘要：
As a member of vector-borne viruses,Zika virus(ZIKV)can cause microcephaly and various neurological symptoms in newborns.Previously,we found that ZIKV could infect hypothalamus,causing a decrease in growth hormone(GH)secretion,growth delay and deficits in learning and memory in suckling mice.Early administration of GH can improve the cognitive function of the mice.Therefore,in this study we further investigated the mechanism underlying the protective role of GH in ZIKV infection in suckling mice.Our results showed that GH could effectively reduce brain damage caused by ZIKV infection via reducing cell apoptosis and inflammatory response rather than inhibiting viral replication.Our results provide important evidences not only for under-standing the mechanism underlying ZIKV-associated neurological symptoms but also for the treatment of ZIKV infection.
文献关键词：
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作者姓名：
Zi-Da Zhen;Na Wu;Dong-Ying Fan;Jun-Hong Ai;Zheng-Ran Song;Jia-Tong Chang;Pei-Gang Wang;Yan-Hua Wu;Jing An
作者机构：
Department of Microbiology,School of Basic Medical Sciences,Capital Medical University,Beijing,100069,China;Laboratory Animal Resource Center,Capital Medical University,Beijing,100069,China
文献出处：
引用格式：
[1]Zi-Da Zhen;Na Wu;Dong-Ying Fan;Jun-Hong Ai;Zheng-Ran Song;Jia-Tong Chang;Pei-Gang Wang;Yan-Hua Wu;Jing An-.Growth hormone attenuates the brain damage caused by ZIKV infection in mice)[J].中国病毒学,2022(04):601-609
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Growth,hormone,attenuates,brain,damage,caused,by,ZIKV,infection,mice,member,vector,borne,viruses,Zika,can,microcephaly,various,neurological,symptoms,newborns,Previously,found,that,could,hypothalamus,causing,decrease,growth,GH,secretion,delay,deficits,learning,memory,suckling,Early,administration,improve,cognitive,function,Therefore,this,study,further,investigated,mechanism,underlying,protective,role,Our,results,showed,effectively,reduce,via,reducing,cell,apoptosis,inflammatory,response,rather,than,inhibiting,viral,replication,provide,important,evidences,not,only,standing,associated,but,also,treatment
AB值：
0.597197
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