This paper presents a meta-analysis regarding the detection rate(DR)of fluorine-18(18F)-labeled prostate-specific membrane antigen positron emission tomography/computed tomography(PSMA PET/CT)in the management of patients with prostate cancer(PCa).Relevant studies regarding 18F-PSMA PET/CT in the management of PCa published until June 1,2021,were electronically searched in online databases including EMBASE,PubMed,and Web of Science.The primary outcome was the DR of 18F-PSMA PET/CT in managing PCa patients,while the secondary outcome was the DR of 18F-PSMA PET/CT according to Gleason scores and serum prostate-specific antigen(PSA)level.The pooled DR was calculated on a per-patient basis,with pooled odd ratios and 95％confidence intervals(CIs).In total,17 observational studies evaluating 1019 patients with PCa met the inclusion criteria.The DR of 18F-PSMA PET/CT was 0.83(95％CI:0.78-0.88),in the random-effects model.Subsequently,the analysis of DR of 18F-PSMA PET/CT in PCa patients using Gleason score(≤7 vs 28)),showed a significant difference in PCa patients.Based on the above results,the higher Gleason score of PCa patients,the higher DR of 18F-PSMA PET/CT.The DR of 18F-PSMA PET/CT in PCa was 0.57 for PSA＜0.5 ng ml-1;0.75 for PSA 20.5 ng ml-1 and＜1.0 ng ml-1;0.93 for PSA 21.0 ng ml-1 and＜2.0 ng ml-1;and 0.95 for PSA 22.0 ng ml-1.Therefore,the significant diagnostic value was found in terms of the DR of 18F-PSMA PET/CT in managing PCa patients and was associated with Gleason score and serum PSA level.

Zhi-Qiang Qin;Gao-Jian Pan;Zheng Xu;Hao Wang;Lu-Wei Xu;Rui-Peng Jia

Department of Urology,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,China;Department of Urology,Yancheng Third People's Hospital,Yancheng 224000,China;Department of Urology,The Yancheng School of Clinical Medicine of Nanjing Medical University,Yancheng 224000,China

亚洲男性学杂志（英文版）

[1]Zhi-Qiang Qin;Gao-Jian Pan;Zheng Xu;Hao Wang;Lu-Wei Xu;Rui-Peng Jia-.The performance of 18F-PSMA PET/CT in the detection of prostate cancer:a systematic review and meta-analysis)[J].亚洲男性学杂志（英文版）,2022(04):373-379

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