典型文献
Fine-tuning T cell function through engineered orthogonal chimeric cytokine receptors
文献摘要：
In a recent study published in Nature,Kalbasi et al.demonstrate that engineering T cells to express a chimeric orthogonal IL-2 receptor,where the intracellular domain(ICD)of the receptor was replaced with the IL-9 receptor ICD,mitigated negative impacts of IL-2 administration and also drove signaling through STAT1,STAT3 and STAT5 to promote anti-tumor function and T cell stemness.
文献关键词：
中图分类号：
作者姓名：
Rigel J.Kishton;Nicholas P.Restifo
作者机构：
Surgery Branch,Center for Cancer Research,National Cancer Institute,Bethesda,MD,USA
文献出处：
引用格式：
[1]Rigel J.Kishton;Nicholas P.Restifo-.Fine-tuning T cell function through engineered orthogonal chimeric cytokine receptors)[J].细胞研究（英文版）,2022(11):967-968
A类：
Kalbasi
B类：
Fine,tuning,function,through,engineered,orthogonal,chimeric,cytokine,receptors,In,recent,study,published,Nature,et,demonstrate,that,engineering,cells,express,where,intracellular,domain,ICD,was,replaced,mitigated,negative,impacts,administration,also,drove,signaling,STAT1,STAT3,STAT5,promote,anti,tumor,stemness
AB值：
0.694048
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