典型文献
Transcription factor Klf9 controls bile acid reabsorption and enterohepatic circulation in mice via promoting intestinal Asbt expression
文献摘要：
Bile acid(BA)homeostasis is regulated by the extensive cross-talk between liver and intestine.Many bile-acid-activated signaling pathways have become attractive therapeutic targets for the treatment of metabolic disorders.In this study we investigated the regulatory mechanisms of BA in the intestine.We showed that the BA levels in the gallbladder and faeces were significantly increased,whereas serum BA levels decreased in systemic Krüppel-like factor 9(Klf9)deficiency(Klf9-/-)mice.These phenotypes were also observed in the intestine-specific Klf9-deleted(Klf9vil-/-)mice.In contrast,BA levels in the gallbladder and faeces were reduced,whereas BA levels in the serum were increased in intestinal Klf9 transgenic(Klf9Rosa26+/+)mice.By using a combination of biochemical,molecular and functional assays,we revealed that Klf9 promoted the expression of apical sodium-dependent bile acid transporter(Asbt)in the terminal ileum to enhance BA absorption in the intestine.Reabsorbed BA affected liver BA synthetic enzymes by regulating Fgf15 expression.This study has identified a previously neglected transcriptional pathway that regulates BA homeostasis.
文献关键词：
中图分类号：
作者姓名：
Shuang Liu;Man Liu;Meng-lin Zhang;Cui-zhe Wang;Yin-liang Zhang;Yu-jie Zhang;Chun-yuan Du;Su-fang Sheng;Wei Wang;Ya-tong Fan;Jia-ni Song;Jin-can Huang;Yue-yao Feng;Wei Qiao;Jin-long Huang;Yu-hui Li;Lu Zhou;Jun Zhang;Yong-sheng Chang
作者机构：
Key Laboratory of Immune Microenvironment and Disease(Ministry of Education),Tianjin Key Laboratory of Cellular Homeostasis and Disease,Department of Physiology and Pathophysiology,Tianjin Medical University,Tianjin 300052,China;Department of Basic Medicine,Shihezi University School of Medicine,Shihezi 832000,China;Key Laboratory of Biotechnology of Hubei Province,Key Laboratory of Biotechnology of Chinese Traditional Medicine,National&Local Joint Engineering Research Center of High-throughput Drug Screening Technology,Hubei University,Wuhan 430062,China;Department of Gastroenterology and Hepatology,Tianjin Medical University General Hospital,Tianjin 300052,China
文献出处：
引用格式：
[1]Shuang Liu;Man Liu;Meng-lin Zhang;Cui-zhe Wang;Yin-liang Zhang;Yu-jie Zhang;Chun-yuan Du;Su-fang Sheng;Wei Wang;Ya-tong Fan;Jia-ni Song;Jin-can Huang;Yue-yao Feng;Wei Qiao;Jin-long Huang;Yu-hui Li;Lu Zhou;Jun Zhang;Yong-sheng Chang-.Transcription factor Klf9 controls bile acid reabsorption and enterohepatic circulation in mice via promoting intestinal Asbt expression)[J].中国药理学报（英文版）,2022(09):2362-2372
A类：
Klf9,Asbt,Klf9vil,Klf9Rosa26+,Reabsorbed,Fgf15
B类：
Transcription,controls,bile,acid,reabsorption,enterohepatic,circulation,mice,via,promoting,intestinal,expression,Bile,BA,homeostasis,regulated,by,extensive,cross,talk,between,liver,intestine,Many,activated,signaling,pathways,have,become,attractive,therapeutic,targets,treatment,metabolic,disorders,In,this,study,investigated,regulatory,mechanisms,We,showed,that,levels,gallbladder,faeces,were,significantly,increased,whereas,serum,decreased,systemic,Kr,ppel,like,deficiency,These,phenotypes,also,observed,specific,deleted,contrast,reduced,transgenic,By,using,combination,biochemical,molecular,functional,assays,revealed,promoted,apical,sodium,dependent,transporter,terminal,ileum,enhance,affected,synthetic,enzymes,regulating,This,has,identified,previously,neglected,transcriptional,regulates
AB值：
0.533717
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
