典型文献
Secure Scheme for Locating Disease-Causing Genes Based on Multi-Key Homomorphic Encryption
文献摘要：
Genes have great significance for the prevention and treatment of some diseases.A vital consideration is the need to find a way to locate pathogenic genes by analyzing the genetic data obtained from different medical institutions while protecting the privacy of patients'genetic data.In this paper,we present a secure scheme for locating disease-causing genes based on Multi-Key Homomorphic Encryption(MKHE),which reduces the risk of leaking genetic data.First,we combine MKHE with a frequency-based pathogenic gene location function.The medical institutions use MKHE to encrypt their genetic data.The cloud then homomorphically evaluates specific gene-locating circuits on the encrypted genetic data.Second,whereas most location circuits are designed only for locating monogenic diseases,we propose two location circuits(TH-intersection and Top-q)that can locate the disease-causing genes of polygenic diseases.Third,we construct a directed decryption protocol in which the users involved in the homomorphic evaluation can appoint a target user who can obtain the final decryption result.Our experimental results show that compared to the JWB+17 scheme published in the journal Science,our scheme can be used to diagnose polygenic diseases,and the participants only need to upload their encrypted genetic data once,which reduces the communication traffic by a few hundred-fold.
文献关键词：
中图分类号：
作者姓名：
Tanping Zhou;Wenchao Liu;Ningbo Li;Xiaoyuan Yang;Yiliang Han;Shangwen Zheng
作者机构：
College of Cryptography Engineering,Engineering University of People's Armed Police,Xi'an 710086,China,and with TCA Laboratory,State Key Laboratory of Computer Science,Institute of Software,Chinese Academy of Sciences,Beijing 100080,China;College of Cryptography Engineering,Engineering University of People's Armed Police,Xi'an 710086,China;People's Armed Police Command College China,Tianjin 300100,China
文献出处：
引用格式：
[1]Tanping Zhou;Wenchao Liu;Ningbo Li;Xiaoyuan Yang;Yiliang Han;Shangwen Zheng-.Secure Scheme for Locating Disease-Causing Genes Based on Multi-Key Homomorphic Encryption)[J].清华大学学报自然科学版（英文版）,2022(02):333-343
A类：
Causing,MKHE,homomorphically,appoint,JWB+17
B类：
Secure,Scheme,Locating,Disease,Genes,Based,Multi,Key,Homomorphic,Encryption,have,great,significance,prevention,treatment,some,diseases,vital,consideration,need,find,way,locate,pathogenic,genes,by,analyzing,genetic,data,obtained,from,different,medical,institutions,while,protecting,privacy,patients,In,this,paper,we,present,secure,scheme,locating,causing,which,reduces,risk,leaking,First,combine,frequency,location,function,their,cloud,then,evaluates,specific,circuits,encrypted,Second,whereas,most,designed,only,monogenic,propose,two,TH,intersection,Top,that,polygenic,Third,construct,directed,decryption,protocol,users,involved,evaluation,target,who,final,Our,experimental,results,show,compared,published,journal,be,used,diagnose,participants,upload,once,communication,traffic,few,hundred,fold
AB值：
0.522979
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