典型文献
A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication
文献摘要：
The process of domestication has led to dramatic differences in behavioral traits between domestic dogs and gray wolves.Whole-genome research found that a class of putative positively selected genes were related to various aspects of learning and memory,such as long-term potentiation and long-term depression.In this study,we constructed a single-nucleus transcriptomic atlas of the dog hippocampus to illustrate its cell types,cell lineage and molecular features.Using the transcriptomes of 105 057 nuclei from the hippocampus of a Beagle dog,we identified 26 cell clusters and a putative trajectory of oligodendrocyte development.Comparative analysis revealed a significant convergence between dog differentially expressed genes(DEGs)and putative positively selected genes(PSGs).Forty putative PSGs were DEGs in glutamatergic neurons,especially in Cluster 14,which is related to the regulation of nervous system development.In summary,this study provides a blueprint to understand the cellular mechanism of dog domestication.
文献关键词：
中图分类号：
作者姓名：
Qi-Jun Zhou;Xingyan Liu;Longlong Zhang;Rong Wang;Tingting Yin;Xiaolu Li;Guimei Li;Yuqi He;Zhaoli Ding;Pengcheng Ma;Shi-Zhi Wang;Bingyu Mao;Shihua Zhang;Guo-Dong Wang
作者机构：
State Key Laboratory of Genetic Resources and Evolution,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming 650223,China;NCMIS,CEMS,RCSDS,Academy of Mathematics and Systems Science,Chinese Academy of Sciences,Beijing 100190,China;School of Mathematical Sciences University of Chinese Academy of Sciences Beijing 100049,China;Kunming College of Life Science University of Chinese Academy of Sciences,Kunming 650223 China;College of Life Science,University of Chinese Academy of Sciences Beijing 100049,China;Genomic Center of Biodiversity Kunming institute of Zoology Chinese Academy of Sciences,Kunming 650223,China;Center for Excellence in Animal Evolution and Genetics,Chinese Academy of Sciences Kunming 650223 China;Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China
文献出处：
引用格式：
[1]Qi-Jun Zhou;Xingyan Liu;Longlong Zhang;Rong Wang;Tingting Yin;Xiaolu Li;Guimei Li;Yuqi He;Zhaoli Ding;Pengcheng Ma;Shi-Zhi Wang;Bingyu Mao;Shihua Zhang;Guo-Dong Wang-.A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication)[J].国家科学评论（英文版）,2022(11):103-115
A类：
PSGs
B类：
single,nucleus,transcriptomic,atlas,hippocampus,reveals,potential,relationship,between,specific,types,domestication,process,has,dramatic,differences,behavioral,traits,dogs,gray,wolves,Whole,genome,research,found,that,class,putative,positively,selected,genes,were,related,various,aspects,learning,memory,such,long,term,potentiation,depression,In,this,study,constructed,illustrate,lineage,molecular,features,Using,transcriptomes,nuclei,from,Beagle,identified,clusters,trajectory,oligodendrocyte,development,Comparative,analysis,revealed,significant,convergence,differentially,expressed,DEGs,Forty,glutamatergic,neurons,especially,Cluster,which,regulation,nervous,system,summary,provides,blueprint,understand,cellular,mechanism
AB值：
0.581692
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