典型文献
The distinct morphological phenotypes of Southeast Asian aborigines are shaped by novel mechanisms for adaptation to tropical rainforests
文献摘要：
Southeast Asian aborigines,the hunter-gatherer populations living in tropical rainforests,exhibit distinct morphological phenotypes,including short stature,dark skin,curly hair and a wide and snub nose.The underlying genetic architecture and evolutionary mechanism of these phenotypes remain a long-term mystery.We conducted whole genome deep sequencing of 81 Cambodian aborigines from eight ethnic groups.Through a genome-wide scan of selective sweeps,we discovered key genes harboring Cambodian-enriched mutations that may contribute to their phenotypes,including two hair morphogenesis genes(TCHH and TCHHL1),one nasal morphology gene(PAX3)and a set of genes(such as ENTPD1-AS1)associated with short stature.The identified new genes and novel mutations suggest an independent origin of the distinct phenotypes in Cambodian aborigines through parallel evolution,refuting the long-standing argument on the common ancestry of these phenotypes among the worldwide rainforest hunter-gatherers.Notably,our discovery reveals that various types of molecular mechanisms,including antisense transcription and epigenetic regulation,contribute to human morphogenesis,providing novel insights into the genetics of human environmental adaptation.
文献关键词：
中图分类号：
作者姓名：
Xiaoming Zhang;Qi Liu;Hui Zhang;Shilei Zhao;Jiahui Huang;Tuot Sovannary;Long Bunnath;Hong Seang Aun;Ham Samnom;Bing Su;Hua Chen
作者机构：
State Key Laboratory of Genetic Resources and Evolution,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming 650223,China;Center for Excellence in Animal Evolution and Genetics,Chinese Academy of Sciences,Kunming 650223,China;CAS Key Laboratory of Genomic and Precision Medicine,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100101,China;China National Center for Bioinformation,Beijing 100101,China;School of Future Technology and Sino-Danish College,University of Chinese Academy of Sciences,Beijing 100049,China;Kunming College of Life Science,University of Chinese Academy of Sciences,Beijing 100101,China;Department of Geography and Land Management,Royal University of Phnom Penh,Phnom Penh 12000,Cambodia;Capacity Development Facilitator for Handicap International Federation and Freelance Research,Battambang 02358,Cambodia
文献出处：
引用格式：
[1]Xiaoming Zhang;Qi Liu;Hui Zhang;Shilei Zhao;Jiahui Huang;Tuot Sovannary;Long Bunnath;Hong Seang Aun;Ham Samnom;Bing Su;Hua Chen-.The distinct morphological phenotypes of Southeast Asian aborigines are shaped by novel mechanisms for adaptation to tropical rainforests)[J].国家科学评论（英文版）,2022(03):81-91
A类：
aborigines,gatherer,snub,Cambodian,TCHH,TCHHL1,ENTPD1,refuting,gatherers
B类：
distinct,morphological,phenotypes,Southeast,Asian,are,shaped,by,novel,mechanisms,adaptation,tropical,rainforests,hunter,populations,living,exhibit,including,short,stature,dark,skin,curly,hair,nose,underlying,architecture,evolutionary,these,remain,long,term,mystery,We,conducted,whole,genome,deep,sequencing,from,eight,ethnic,groups,Through,scan,selective,sweeps,discovered,key,harboring,enriched,mutations,that,may,contribute,their,two,morphogenesis,one,nasal,morphology,PAX3,set,such,AS1,associated,identified,new,suggest,independent,through,parallel,standing,argument,common,ancestry,among,worldwide,Notably,our,discovery,reveals,various,molecular,antisense,transcription,epigenetic,regulation,human,providing,insights,into,genetics,environmental
AB值：
0.51935
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
