典型文献
Mass Transfer,Gas Holdup,and Kinetic Models of Batch and Continuous Fermentation in a Novel Rectangular Dynamic Membrane Airlift Bioreactor
文献摘要：
Compared with conventional cylinder airlift bioreactors(CCABs)that produce coarse bubbles,a novel rectangular dynamic membrane airlift bioreactor(RDMAB)developed in our lab produces fine bubbles to enhance the volumetric oxygen mass transfer coefficient(kLa)and gas holdup,as well as improve the bioprocess in a bioreactor.In this study,we compared mass transfer,gas holdup,and batch and con-tinuous fermentation for RNA production in CCAB and RDMAB.In addition,unstructured kinetic models for microbial growth,substrate utilization,and RNA formation were established.In batch fermentation,biomass,RNA yield,and substrate utilization in the RDMAB were higher than those in the CCAB,which indicates that dynamic membrane aeration produced a high kLa by fine bubbles;a higher kLa is more bene-ficial to aerobic fermentation.The starting time of continuous fermentation in the RDMAB was 20 h ear-lier than that in the CCAB,which greatly improved the biological process.During continuous fermentation,maintaining the same dissolved oxygen level and a constant dilution rate,the biomass accumulation and RNA concentration in the RDMAB were 9.71％and 11.15％higher than those in the CCAB,respectively.Finally,the dilution rate of RDMAB was 16.7％higher than that of CCAB during con-tinuous fermentation while maintaining the same air aeration.In summary,RDMAB is more suitable for continuous fermentation processes.Developing new aeration and structural geometry in airlift bioreac-tors to enhance kLa and gas holdup is becoming increasingly important to improve bioprocesses in a bioreactor.
文献关键词：
中图分类号：
作者姓名：
Ganlu Li;Kequan Chen;Yanpeng Wei;Jinlei Zeng;Yue Yang;Feng He;Hui Li;Pingkai Ouyang
作者机构：
College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University,Nanjing 211816,China;Jiangsu Jicui Industrial Biotechnology Research Institute Co.,Ltd.,Nanjing 211800,China
文献出处：
引用格式：
[1]Ganlu Li;Kequan Chen;Yanpeng Wei;Jinlei Zeng;Yue Yang;Feng He;Hui Li;Pingkai Ouyang-.Mass Transfer,Gas Holdup,and Kinetic Models of Batch and Continuous Fermentation in a Novel Rectangular Dynamic Membrane Airlift Bioreactor)[J].工程（英文）,2022(06):153-163
A类：
Holdup,Airlift,Bioreactor,airlift,CCABs,RDMAB,bioprocess,CCAB,bioreac
B类：
Mass,Transfer,Gas,Kinetic,Models,Batch,Continuous,Fermentation,Novel,Rectangular,Dynamic,Membrane,Compared,conventional,cylinder,bioreactors,that,coarse,bubbles,novel,rectangular,dynamic,membrane,developed,our,lab,produces,fine,enhance,volumetric,oxygen,transfer,coefficient,kLa,gas,holdup,well,In,this,study,compared,batch,fermentation,production,addition,unstructured,kinetic,models,microbial,growth,substrate,utilization,formation,were,established,biomass,yield,higher,than,those,which,indicates,aeration,produced,by,more,bene,ficial,aerobic,starting,continuous,was,ear,lier,greatly,improved,biological,During,maintaining,same,dissolved,level,constant,dilution,accumulation,concentration,respectively,Finally,during,while,summary,suitable,Developing,new,structural,geometry,becoming,increasingly,important,bioprocesses
AB值：
0.417196
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