典型文献
Comparative Analysis of Hydration Layer Reorientation Dynamics of Antifreeze Protein and Protein Cytochrome P450
文献摘要：
Antifreeze proteins(AFPs)inhibit ice re-crystallization by a mechanism remaining largely elusive.Dynam-ics of AFPs'hydration water and its involve-ment in the antifreeze activity have not been identified conclusively.We herein,by simulation and theory,examined the water reorientation dynamics in the first hydration layer of an AFP from the spruce budworm,Choristoneura fumiferana,compared with a protein cytochrome P450(CYP).The increase of potential acceptor water molecules around donor water molecules leads to the acceleration of hydrogen bond exchange between water molecules.Therefore,the jump reorientation of water molecules around the AFP active region is accelerated.Due to the mutual coupling and excitation of hydrogen bond exchange,with the acceleration of hydrogen bond exchange,the rearrangement of the hydrogen bond network and the frame reorientation of water are accelerated.Therefore,the water reorientation dynamics of AFP is faster than that of CYP.The results of this study provide a new physical image of antifreeze protein and a new understanding of the antifreeze mechanism of antifreeze proteins.
文献关键词：
中图分类号：
作者姓名：
Hongfeng Yu;Qiang Zhang;Wei Zhuang
作者机构：
State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou 350002,China;University of Chinese Academy of Sciences,Beijing 100049,China;College of Chemistry and Material Sciences,Inner Mongolia Minzu University,Tongliao 028043,China;Institute of Urban Environment,Chinese Academy of Sciences,Xiamen 361021,China
文献出处：
引用格式：
[1]Hongfeng Yu;Qiang Zhang;Wei Zhuang-.Comparative Analysis of Hydration Layer Reorientation Dynamics of Antifreeze Protein and Protein Cytochrome P450)[J].化学物理学报（英文版）,2022(03):509-515
A类：
Reorientation,Antifreeze,AFPs,Dynam,budworm,Choristoneura,fumiferana
B类：
Comparative,Analysis,Hydration,Layer,Dynamics,Protein,Cytochrome,P450,proteins,inhibit,ice,crystallization,by,mechanism,remaining,largely,elusive,hydration,water,its,involve,antifreeze,activity,have,not,been,identified,conclusively,We,herein,simulation,theory,examined,reorientation,dynamics,first,layer,from,spruce,compared,cytochrome,CYP,increase,potential,acceptor,molecules,around,donor,leads,acceleration,hydrogen,bond,exchange,between,Therefore,jump,active,region,accelerated,Due,mutual,coupling,excitation,rearrangement,network,frame,faster,than,that,results,this,study,provide,new,physical,image,understanding
AB值：
0.472991
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