典型文献
Visceral debranching followed by chemotherapy and resection for locally advanced pancreatic cancer with arterial invasion: case report
文献摘要：
The oncological outcome of patients with locally advanced pancreatic cancer continues to be dismal. Abutment or invasion of visceral arteries, which constitutes irresectability according to the consensus of the International Association of Pancreatology and can be found in a considerable proportion of patients upon initial diagnosis, usually precludes complete resection in curative intent. Simultaneous tumor resection and arterial reconstruction are associated with relevant morbidity and mortality. Here, we present a case in which a therapeutic split was done so that isolated arterial reconstruction (visceral debranching with an iliacohepatic bypass graft) preceded neoadjuvant FOLFIRINOX chemotherapy and subsequent multivisceral tumor resection. Despite several perioperative vascular complications, which were addressed by surgical and endovascular techniques, the patient had a favorable outcome of the operations and is tumor-free after 8 months of follow-up. The feasibility and safety of this novel therapeutic strategy of a therapeutic split with isolated visceral debranching as the first treatment step is currently evaluated in a clinical trial (PREVADER, NCT04136769).
文献关键词：
Arterial reconstruction;Pancreatic cancer;Preoperative chemotherapy;Therapeutic split
中图分类号：
作者姓名：
Ronellenfitsch Ulrich;Rebelo Artur;Kleeff Jorg
作者机构：
Department of Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
文献出处：
引用格式：
[1]Ronellenfitsch Ulrich;Rebelo Artur;Kleeff Jorg-.Visceral debranching followed by chemotherapy and resection for locally advanced pancreatic cancer with arterial invasion: case report)[J].胰腺病学杂志（英文）,2022(03):134-136
A类：
Abutment,irresectability,Pancreatology,precludes,iliacohepatic,multivisceral,PREVADER,NCT04136769
B类：
Visceral,debranching,followed,chemotherapy,resection,locally,advanced,pancreatic,cancer,arterial,invasion,case,report,oncological,outcome,patients,continues,be,dismal,arteries,which,constitutes,according,consensus,International,Association,found,considerable,proportion,upon,initial,diagnosis,usually,complete,curative,intent,Simultaneous,tumor,reconstruction,are,associated,relevant,morbidity,mortality,Here,present,therapeutic,split,was,done,that,isolated,bypass,graft,preceded,neoadjuvant,FOLFIRINOX,subsequent,Despite,several,perioperative,complications,were,addressed,surgical,endovascular,techniques,had,favorable,operations,free,after,months,feasibility,safety,this,novel,strategy,first,treatment,step,currently,evaluated,clinical,trial,Arterial,Pancreatic,Preoperative,Therapeutic
AB值：
0.548734
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