典型文献
Placental pathologies and fetal outcome in pregnant women with COVID-19: A retrospective study
文献摘要：
Objective: To describe histopathologic findings in the placentas in women with coronavirus disease 2019 (COVID-19) during pregnancy. Methods: In a cross-sectional study, 38 pregnant women with COVID-19 and undergoing delivery between March 2020 and January 2022, were included. The patients had positive polymerase chain reaction (PCR) test for SARS-CoV-2 infection and the placentas after delivery were sent for histopathologic evaluation based on the Amsterdam Placental Workshop Group Consensus Statement and assessed by two pathologists. Results: Our results showed that maternal vascular malperfusion was the most common and was present in 17 cases (44.7％). These features included accelerated villous maturation (36.8％) distal villous hypoplasia (5.3％), placental infarction (5.3％) and intervillous fibrin deposition (10.5％). Other pathologic findings included focal calcification (10.5％), intravillous congestion and hemorrhage (10.5％), sub-chorionic hemorrhage (5.3％), acute villitis, chronic histiocytic intervillositis and delayed villous maturation each in one case (2.6％). Twelve out of 38 cases showed no significant pathologic changes. Fetal outcomes included neonatal intensive care unit admission rate of 13.2％, dyspnea 31.6％, newborn's anosmia 7.9％, intrauterine fetal demise 2.6％, asphyxia 2.6％ and neonate COVID infection 5.3％. Conclusions: Microvasculopathy, as a sign of maternal vascular malperfusion, is a common finding in placentas from SARS-CoV-2 positive pregnant women in the present study. Further studies with larger sample sizes and comparative studies between COVID-19 positive and negative, as well as information from patient follow-up are suggested.
文献关键词：
中图分类号：
作者姓名：
Soheila Sarmadi;Ara Omranipour;Elham Mirzaian;Roghayyeh Ahangari;Zahra Yazdi;Azadeh Asgarian;Monireh Mirzaie
作者机构：
Department of Pathology,Yas Hospital,Tehran University of Medical Sciences,Tehran,Iran;Department of Obstetrics and Gynecology,School of Medicine,Shahid Beheshti Hospital,Qom University of Medical Sciences,Qom,Iran;Department of Pathology,Shariati Hospital,School of Medicine,Tehran University of Medical Sciences,Tehran,Iran;Department of Obstetrics and Gynecology,Clinical Research Development Unit,School of Medicine,Nekouei-Hedayati-Forghani Hospital,Qom University of Medical Sciences,Qom,Iran;Department of Nursing,Clinical Research Development Unit,Nekouei-Hedayati-Forghani Hospital,Qom University of Medical Sciences,Qom,Iran
文献出处：
引用格式：
[1]Soheila Sarmadi;Ara Omranipour;Elham Mirzaian;Roghayyeh Ahangari;Zahra Yazdi;Azadeh Asgarian;Monireh Mirzaie-.Placental pathologies and fetal outcome in pregnant women with COVID-19: A retrospective study)[J].亚太生殖杂志（英文版）,2022(03):132-137,中插1-中插3
A类：
placentas,pathologists,villous,intervillous,intravillous,intervillositis,Microvasculopathy
B类：
Placental,pathologies,fetal,pregnant,women,retrospective,study,Objective,To,describe,histopathologic,findings,coronavirus,disease,during,pregnancy,Methods,In,cross,sectional,undergoing,delivery,between,March,January,were,included,patients,had,positive,polymerase,chain,reaction,test,SARS,CoV,infection,after,evaluation,Amsterdam,Workshop,Group,Consensus,Statement,assessed,by,two,Results,Our,results,showed,that,maternal,vascular,malperfusion,was,most,common,present,cases,These,features,accelerated,maturation,distal,hypoplasia,placental,infarction,fibrin,deposition,Other,focal,calcification,congestion,hemorrhage,sub,chorionic,acute,villitis,chronic,histiocytic,delayed,each,one,Twelve,significant,changes,Fetal,outcomes,neonatal,intensive,care,unit,admission,dyspnea,newborn,anosmia,intrauterine,demise,asphyxia,neonate,Conclusions,from,Further,studies,larger,sample,sizes,comparative,negative,well,information,follow,suggested
AB值：
0.568978
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