典型文献
Generation of Plvap-CreER and Car4-CreER for genetic targeting of distinct lung capillary populations
文献摘要：
It has been reported recently that there are two distinct subpopulations of capillary endothelial cells in the mammalian lungs:gCap(general capillary)and aCap(aerocyte).They are identified by two unique markers,respectively:plasmalemmal vesicle-associated protein(PLVAP)and carbonic anhydrase Ⅳ(CAR4).Here,we report two novel knock-in mouse lines Plvap-CreER and Car4-CreER,which genetically target gCap and aCap,respectively.Induced by tamoxifen,the Plvap-CreER and Car4-CreER alleles mediate specific and efficient Cre-IoxP recombinations in PLVAP+gCap and CAR4+aCap,respectively,in the lungs.These two mouse lines are useful genetic tools to investigate cell fates and functions of PLVAP+and CAR4+cells in lung homeostasis,injury and repair.
文献关键词：
中图分类号：
作者姓名：
Zhenqian Zhang;Bin Zhou
作者机构：
State Key Laboratory of Cell Biology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences;University of Chinese Academy of Sciences,Shanghai 200031,China;Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou,Zhejiang 310024,China;School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China
文献出处：
引用格式：
[1]Zhenqian Zhang;Bin Zhou-.Generation of Plvap-CreER and Car4-CreER for genetic targeting of distinct lung capillary populations)[J].遗传学报,2022(12):1093-1100
A类：
Plvap,CreER,Car4,gCap,aCap,aerocyte,plasmalemmal,PLVAP,CAR4,IoxP,PLVAP+gCap,CAR4+aCap,PLVAP+and,CAR4+cells
B类：
Generation,targeting,distinct,capillary,It,has,been,reported,recently,that,there,are,two,subpopulations,endothelial,mammalian,lungs,general,They,identified,by,unique,markers,respectively,vesicle,associated,protein,carbonic,anhydrase,Here,we,novel,knock,mouse,lines,which,genetically,Induced,tamoxifen,alleles,mediate,specific,efficient,recombinations,These,useful,tools,investigate,fates,functions,homeostasis,injury,repair
AB值：
0.401189
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