Air consists of various different pollutants(both biological and non-biological).COVID-19 pandemic further threatens the air safety.Aerosol exposure causes many diseases including asthma,respiratory infections and death.Using protein bi-omarker for early diagnosis often fails due to its lower level at the very beginning of a disease.On another front,different technologies were attempted for realtime monitoring of air toxicity.Nonetheless,many aerosol exposures occur silently without any knowledge due to limitation of available analytical methods.Exhaled breath has emerged as a promising non-invasive sample for disease diagnosis,in-cluding cancer and diabetes.Most recently,it was shown that rats emitted distinc-tive profile of volatile organic compounds(VOCs)within minutes when exposed to different air pollutants including ozone and endotoxin.During the pandemic times,breath-borne VOC was also used to rapidly screen COVID-19.Pollutant exposure could result in changes in metabolism,thus releasing different pat-terns of VOCs via breath within very short time.Close monitoring of exhaled biomarker profile could spot the early signs of a disease,thus offering an earlier warning.Sensor array and machine learning together can lend a great hand toward such an objective.This mini review is undertaken to share such endeavors and inspire further innovations.

Maosheng Yao

State Key Joint Laboratory of Environmental Simulation and Pollution Control,College of Environmental Sciences and Engineering,Peking University,Beijing 100871,China

中国化学（英文版）

[1]Maosheng Yao-."Smoke Detector"of Human Diseases for Environmental Aerosol Exposure)[J].中国化学（英文版）,2022(12):1471-1477

omarker,silently,distinc

Smoke,Detector,Human,Diseases,Environmental,Aerosol,Exposure,Air,consists,various,different,pollutants,both,biological,pandemic,further,threatens,air,safety,causes,many,diseases,including,asthma,respiratory,infections,death,Using,protein,early,diagnosis,often,fails,due,its,lower,level,very,beginning,On,another,front,technologies,were,attempted,realtime,monitoring,toxicity,Nonetheless,aerosol,exposures,occur,without,knowledge,limitation,available,analytical,methods,Exhaled,breath,has,emerged,promising,invasive,sample,cancer,diabetes,Most,recently,was,shown,that,rats,emitted,profile,volatile,organic,compounds,VOCs,within,minutes,when,exposed,ozone,endotoxin,During,times,borne,also,used,rapidly,screen,Pollutant,could,result,changes,metabolism,thus,releasing,pat,terns,via,short,Close,exhaled,biomarker,spot,signs,offering,earlier,warning,Sensor,array,machine,learning,together,lend,great,hand,toward,such,objective,This,mini,review,undertaken,share,endeavors,inspire,innovations

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