典型文献
Discovery of New Bohemamines and Synthesis of Methylene-Bridged Chimeric Derivatives through Natural Product Chimera Strategy
文献摘要：
Five new pyrrolizidine alkaloids,bohemamines J—N(1-5),were isolated from Streptomyces sp.CPCC 200497.Their structures were assigned based on detailed spectroscopic analysis and semisynthesis.Bohemamine J(1)possesses a new chimeric skeleton derived from bohemamine A(6)and phenylacetaldehyde.Inspired by the nonenzymatic formation mechanism of the methylene-bridged dimers isolated from this strain,we synthesized a series of chimeric derivatives(8,9,and 12-23)through natural product chimera strategy.Compounds 13,15,19,and 21 showed significant antioxidant activity.
文献关键词：
中图分类号：
作者姓名：
Rongxin Zhang;Xiaotang Yan;Shupeng Yin;Weihong Wang;Weiming Zhu;Peng Fu
作者机构：
Key Laboratory of Marine Drugs,Ministry of Education of China,School of Medicine and Pharmacy,Ocean University of China,Qingdao,Shandong 266003,China;Laboratory for Marine Drugs and Bioproducts,Pilot National Laboratory for Marine Science and Technology(Qingdao),Qingdao,Shandong 266237,China
文献出处：
引用格式：
[1]Rongxin Zhang;Xiaotang Yan;Shupeng Yin;Weihong Wang;Weiming Zhu;Peng Fu-.Discovery of New Bohemamines and Synthesis of Methylene-Bridged Chimeric Derivatives through Natural Product Chimera Strategy)[J].中国化学（英文版）,2022(12):1413-1421
A类：
Bohemamines,Bridged,bohemamines,semisynthesis,Bohemamine,bohemamine,phenylacetaldehyde
B类：
Discovery,New,Synthesis,Methylene,Chimeric,Derivatives,through,Natural,Product,Chimera,Strategy,Five,new,pyrrolizidine,alkaloids,were,isolated,from,Streptomyces,CPCC,Their,structures,assigned,detailed,spectroscopic,analysis,possesses,chimeric,skeleton,derived,Inspired,by,nonenzymatic,formation,mechanism,methylene,bridged,dimers,this,strain,synthesized,series,derivatives,natural,product,chimera,strategy,Compounds,showed,significant,antioxidant,activity
AB值：
0.685288
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
