典型文献
Diffusion process in enzyme-metal hybrid catalysts
文献摘要：
Enzyme-metal hybrid catalysts bridge the gap between enzymatic and heterogeneous catalysis,which is significant for expanding biocatalysis to a broader scope.Previous studies have demonstrated that the enzyme-metal hybrid catalysts exhibited considerably higher catalytic efficiency in cascade reactions,compared with that of the combination of separated enzyme and metal catalysts.However,the precise mechanism of this phenomenon remains unclear.Here,we investigated the diffusion process in enzyme-metal hybrid catalysts using Pd/lipase-Pluronic conjugates and the combination of immobilized lipase(Novozyme 435)and Pd/C as models.With reference to experimental data in previous studies,the Weisz-Prater parameter and efficiency factor of internal diffusion were calculated to evaluate the internal diffusion limitations in these catalysts.Thereafter,a kinetic model was developed and fitted to describe the proximity effect in hybrid catal-ysts.Results indicated that the enhanced catalytic effici-ency of hybrid catalysts may arise from the decreased internal diffusion limitation,size effect of Pd clusters and proximity of the enzyme and metal active sites,which provides a theoretical foundation for the rational design of enzyme-metal hybrid catalysts.
文献关键词：
中图分类号：
作者姓名：
Shitong Cui;Jun Ge
作者机构：
Key Lab for Industrial Biocatalysis,Ministry of Education,Department of Chemical Engineering,Tsinghua University,Beijing 100084,China;Institute of Biopharmaceutical and Health Engineering,Tsinghua Shenzhen International Graduate School,Shenzhen 518055,China
文献出处：
引用格式：
[1]Shitong Cui;Jun Ge-.Diffusion process in enzyme-metal hybrid catalysts)[J].化学科学与工程前沿,2022(06):921-929
A类：
Novozyme,Weisz,Prater,ysts,effici
B类：
Diffusion,process,enzyme,metal,hybrid,catalysts,Enzyme,bridge,gap,between,enzymatic,heterogeneous,which,significant,expanding,biocatalysis,broader,scope,Previous,studies,have,demonstrated,that,exhibited,considerably,higher,catalytic,efficiency,cascade,reactions,compared,combination,separated,However,precise,mechanism,this,phenomenon,remains,unclear,Here,investigated,diffusion,using,Pd,lipase,Pluronic,conjugates,immobilized,models,With,reference,experimental,data,previous,parameter,internal,were,calculated,evaluate,limitations,these,Thereafter,kinetic,was,developed,fitted,describe,proximity,effect,Results,indicated,enhanced,may,arise,from,decreased,size,clusters,active,sites,provides,theoretical,foundation,rational,design
AB值：
0.517645
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