Antimicrobial material is highly desired because of the increasing demand in biomedical application to prevent from the formation of biofilm.A common strategy for enhancing the antibacterial property of a metal material is to incorporate toxic metal such as Cu and Ag.However,the reported Cu2+ or Ag+ released concentration from antibacterial alloys was much less than the reported minimum inhibitory ion concentrations(MIC),revealing the existence of an unknown alternative antimicrobial mechanism not relying on the toxicity of the metal ions.Herein,we proposed a new antibacterial mechanism that the antibacterial effectiveness of the different alloys is proportional to the micro-area potential differences(MAPDs)on the surface of the alloys.We designed three kinds of Ti-M(M=Zr,Ta and Au)alloys to eliminate the potential antibacterial contribution from Cu and Ag ion.We demonstrated that high MAPDs are associated with great production of reactive oxygen species(ROS),resulting in the killing effect to the biofilm known to be associated with implant infections(Staphlococcus aureus and Escherichia coli).These results provide new insights for the design of antibacterial alloys.

Shan Fu;Yuan Zhang;Yi Yang;Xiaomeng Liu;Xinxin Zhang;Lei Yang;Dake Xu;Fuhui Wang;Gaowu Qin;Erlin Zhang

Key Laboratory for Anisotropy and Texture of Materials(MoE),School of Materials Science and Engineering,Northeastern University,Shenyang 110819,China;Key Laboratory of Material Chemistry for Energy Conversion and Storage(MoE),School of Chemistry and Chemical Engineering,Huazhong University of Science and Technology,Wuhan 430074,China;Research Center for Metallic Wires,Northeastern University,Shenyang 110819,China

材料科学技术（英文版）

[1]Shan Fu;Yuan Zhang;Yi Yang;Xiaomeng Liu;Xinxin Zhang;Lei Yang;Dake Xu;Fuhui Wang;Gaowu Qin;Erlin Zhang-.An antibacterial mechanism of titanium alloy based on micro-area potential difference induced reactive oxygen species)[J].材料科学技术（英文版）,2022(24):75-86

MAPDs,Staphlococcus

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