The brown mussel Perna perna (Linnaeus,1758) is a valuable resource for aquaculture in trop-ical and subtropical coastal regions.It presents desirable characteristics for biomonitoring,including being sessile,widely distributed and abundant,and is a filter-feeder able to ac-cumulate several classes of pollutants (e.g.,metals,hydrocarbons,among others).Mussels' biological responses to pollution exposure can be measured as biomarkers,which include alterations ranging from molecular to physiological levels,to estimate the degree of envi-ronmental contamination and its effects on biota.This full review compiles two decades(2000-2020) of literature concerning biological effects on P.perna mussel caused by environ-mental pollutants (i.e.,metals,hydrocarbons,and emerging pollutants),considering envi-ronmental and farm-based biomonitoring.Biochemical markers related to mussels' oxida-tive status were efficient for the biomonitoring of metals (i.e.,antioxidant enzymes associ-ated with oxidative damage in biomolecules).Genotoxicity and cytotoxicity indicators (i.e.,comet,micronucleus,and neutral red assays) provided a depiction of hydrocarbon contam-ination.The neutral red assay gave a time-concentration cytotoxic response to a wide range of pollutants,including emerging pollutants (e.g.,pharmaceuticals and biocides) and hydro-carbons.Perna perna hemocyte parameters provided a useful approach for biocide biomon-itoring.This paper summarizes useful biomarkers from molecular to physiological levels in this mussel species used to identify and quantify the degree of coastal pollution.An in-tegrated biomarker analysis may provide a way to overcome possible biomarker variations and assess multi-polluted sites.Nevertheless,it is necessary to investigate biomarker vari-ations according to natural factors (e.g.,season and gonad maturation stage) to standardize them for trustworthy biomonitoring.

Fluminense Federal University (UFF),Institute of Biology,Graduate Program in Science and Biotechnology,Mario Santos Braga Street,s/n.Centro,Niterói,RJ CEP 24.020-141,Brazil;Federal University of the State of Rio de Janeiro (UNIRIO),Institute of Biosciences (IBIO),Graduate Program in Neotropical Biodiversity (PPGBIO),Pasteur Avenue,458.Urea,Rio de Janeiro,RJ CEP 22.290-255,Brazil;Fluminense Federal University (UFF),Institute of Biology,Graduate Program in Marine Biology and Coastal Environments,Mario Santos Braga Street,s/n.Centro,Niterói,RJ CEP 24.020-141,Brazil;Federal University of the State of Rio de Janeiro (UNIRIO),Institute of Biosciences (IBIO),Graduate Program in Ecotourism and Conservation,Pasteur Avenue,458.Urea,Rio de Janeiro,RJ CEP 22.290-255,Brazil

[1]Fernanda Silva dos Santos;Raquel A.F.Neves;Mirian Araújo Carlos Crapez;Valéria Laneuville Teixeira;Natascha Krepsky-.How does the brown mussel Perna perna respond to environmental pollution?A review on pollution biomarkers)[J].环境科学学报（英文版）,2022(01):412-428

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