典型文献
Continuous cardiac output measured with a Swan- Ganz catheter reacts too slowly in animal experiments with sudden circulator y failure
文献摘要：
Background : In many animal experiments, it is vital to detect sudden changes in car-diac output (CO). This porcine study compared CO that was measured with a Swan- Ganz pulmonary catheter with the gold standard (which was a transit- time flow probe around the pulmonary artery) during interventions that caused hemodynamic instability. Methods : In one series, 7 pigs were exposed to sudden changes in CO. In another se-ries, 9 pigs experienced more prolonged changes in CO. All the pigs had a Swan- Ganz catheter placed into the pulmonary artery and a flow probe around the pulmonary artery. Adrenaline infusion and controlled hemorrhage were used to increase and de-crease CO, respectively. The measurements of CO before and after each interven-tion were compared for correlation, agreement, and the time delay that it took each method to detect at least a 30％ change in CO. A Bland– Altman test was used to identify correlations and agreements between the methods. Results : In the first series, there was a delay of 5– 7 min for the Swan Ganz catheter to register a 30％ change in cardiac output, compared with the flow probe. However, during prolonged changes in CO in the second series, there was a good correlation between the 2 methods. Mixed venous oxygen saturation reacted faster to changes than did CO; both were measured via the Swan- Ganz catheter. Conclusions : In many animal studies, the use of Swan- Ganz catheters is suitable; how-ever, in experiments with sudden hemodynamic instability, the flow probe is the most advantageous method for measuring CO.
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作者姓名：
Sigríeur Olga Magnúsdóttir;Carsten Simonsen;Bodil Steen Rasmussen;Peter Enemark Lund;Benedict Kj?rgaard
作者机构：
Biomedical Research Laboratory,Aalborg University Hospital,Aalborg,Denmark;Department of Clinical Medicine,Aalborg University,Aalborg,Denmark;Department of Cardiothoracic Surgery,Aalborg University Hospital,Aalborg, Denmark;Department of Anesthesia and Intensive Care,Aalborg University Hospital, Aalborg,Denmark;Unit of Clinical Biostatistics,Aalborg University Hospital,Aalborg,Denmark
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引用格式：
[1]Sigríeur Olga Magnúsdóttir;Carsten Simonsen;Bodil Steen Rasmussen;Peter Enemark Lund;Benedict Kj?rgaard-.Continuous cardiac output measured with a Swan- Ganz catheter reacts too slowly in animal experiments with sudden circulator y failure)[J].动物模型与实验医学（英文）,2022(03):258-265
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0.429893
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