典型文献
Treatment-related adverse events of combined anti-angiogenic and immune checkpoint inhibitors: systematic review and meta-analysis
文献摘要：
Objective Immune checkpoint inhibitor (ICI) plus angiogenesis inhibitor (AI) combination therapy is anovel treatment model for multiple cancers that normalizes vascular-immune crosstalk to potentiate cancer immunity. In this review, we summarize the characteristics of adverse effects (AEs) and all fatal cases reported in clinical studies involing ICI + AI therapy. Methods Four databases were systematically searched for eligible studies, and 28 relevant studies were selected for inclusion. Results Of the patients included, 58.1％ developed grade ≥ 3 AEs. The most common fatal AEs were cardiovascular events, severe infections, and hemorrhage. Compared with AI alone, ICI + AI therapy resulted in more cases of grade ≥ 3 proteinuria, liver injury, and fatal AEs (2.49％ vs. 1.28％, P = 0.0041), especially respiratory toxicities and severe infections; however, ICI + AI therapy reduced hematological toxicity. Conclusion We shared comprehensive and practical safety data to review the adverse events associated with ICI + AI treatment.
文献关键词：
中图分类号：
作者姓名：
Lian Chen;Ling Wu;Zhang Lu;Qin Huang;Liu Huang
作者机构：
Department of Oncology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China
文献出处：
引用格式：
[1]Lian Chen;Ling Wu;Zhang Lu;Qin Huang;Liu Huang-.Treatment-related adverse events of combined anti-angiogenic and immune checkpoint inhibitors: systematic review and meta-analysis)[J].肿瘤学与转化医学（英文）,2022(06):301-310
A类：
anovel,involing
B类：
Treatment,related,adverse,events,combined,anti,angiogenic,immune,checkpoint,inhibitors,review,meta,analysis,Objective,Immune,ICI,plus,angiogenesis,combination,therapy,treatment,model,multiple,cancers,that,normalizes,crosstalk,potentiate,immunity,In,this,summarize,characteristics,effects,AEs,fatal,cases,reported,clinical,studies,Methods,Four,databases,were,systematically,searched,eligible,relevant,selected,inclusion,Results,Of,patients,included,developed,grade,most,common,cardiovascular,severe,infections,hemorrhage,Compared,alone,resulted,more,proteinuria,liver,injury,especially,respiratory,toxicities,however,reduced,hematological,toxicity,Conclusion,We,shared,comprehensive,practical,safety,associated
AB值：
0.606392
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