典型文献
Nasal-type extranodal NK/T cell lymphoma in association with hemophagocytic syndrome: a case report and literature review
文献摘要：
We present a rare case of nasal-type CD56-negative NK/T-cell lymphoma. The patient developed hemophagocytic syndrome during diagnosis and treatment. The patient presented to our hospital (Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) with "nasal congestion for 3 months and scattered erythema, nodules, and ulcers all over the body for 1 month." We analyzed clinical manifestations, skin histopathology, immunohistochemistry, and in situ hybridization results. Histopathology of the skin revealed a moderate amount of atypical lymphocyte infiltration between the entire dermis and collagen bundles. Immunohistochemistry showed the following: CD30 (+), TIA-1 (+), CD3(2GV6) (+), CD5 part (+), CD8 part (+), CD43 (+), CD56 (–), CD4 (–), CD20 (–), PAX5 (–), PCK (–), P63 (–), P40 (–), EGFR (–), Ki-67 (the hot spot LI is approximately 80％), and in situ hybridization EBER-ROCH (+). The diagnosis made was "NK/T cell lymphoma nasal type". This type of lymphoma is aggressive, progresses quickly, and has a poor prognosis. Early clinical manifestations are extremelyatypical, especially in the absence of rash. Analysis of the skin manifestations of the disease has a positive effect on its early diagnosis, early treatment, and prognosis.
文献关键词：
中图分类号：
作者姓名：
Shuang Chen;Yongchu Huang;Yuchun Cao;Yong Zhang
作者机构：
Department of Dermatology and Venereology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
文献出处：
引用格式：
[1]Shuang Chen;Yongchu Huang;Yuchun Cao;Yong Zhang-.Nasal-type extranodal NK/T cell lymphoma in association with hemophagocytic syndrome: a case report and literature review)[J].肿瘤学与转化医学（英文）,2022(02):104-108
A类：
Histopathology,dermis,2GV6,ROCH,extremelyatypical
B类：
Nasal,type,extranodal,NK,cell,lymphoma,association,hemophagocytic,syndrome,case,report,literature,review,We,rare,nasal,CD56,negative,patient,developed,during,diagnosis,treatment,presented,our,hospital,Tongji,Hospital,Medical,College,Huazhong,University,Technology,Wuhan,China,congestion,months,scattered,erythema,nodules,ulcers,over,body,analyzed,clinical,manifestations,skin,histopathology,immunohistochemistry,situ,hybridization,results,revealed,moderate,amount,lymphocyte,infiltration,between,entire,collagen,bundles,Immunohistochemistry,showed,following,CD30,TIA,part,CD8,CD43,CD20,PAX5,PCK,P63,P40,EGFR,Ki,hot,spot,LI,approximately,EBER,made,was,This,aggressive,progresses,quickly,has,poor,prognosis,Early,especially,absence,rash,Analysis,disease,positive,effect,its,early
AB值：
0.605397
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
