Background:Individuals at risk of suffering cardiovascular disease(CVD)present with larger increases in blood triglyceride(TG)concentration after a high-fat meal than do healthy individuals.These postprandial hypertriglyceride levels are an independent risk factor for CVD.Prescription of statins and a bout of prolonged exercise are both effective in lowering postprandial hypertriglyceride levels.We aimed to evaluate the comparative effectiveness of sta-tins vs.a bout of aerobic exercise in reducing fasting and postprandial TG(PPTG)concentrations in individuals at high risk of developing CVD.Methods:Thirty-seven studies from a systematic literature search of the PubMed,EMBASE,and Cochrane databases were included in this review.The selected studies conducted trials involving statin therapy(n=20)or a bout of aerobic exercise(n=19)and measured their impact on PPTG levels as the outcome.Two studies analyzed both treatments and were included in duplicate.The meta-analysis was constructed using a random-effects model to calculate the mean difference(MD).The Student t test was used to compare the data sets for statins vs.exercise.Results:Overall,statin and exercise interventions showed similar reductions in PPTG levels,with an MD of-0.65 mmol/L for statins(95％con-fidence interval(95％CI):-0.54 to-0.77;p＜0.001)and-0.46 mmol/L for exercise(95％CI:-0.21 to-0.71;p＜0.01).However,statins lowered fasting TG levels more than exercise(MD=-1.54 mmol/L,95％CI:-2.25 to-0.83;p=0.009).Conclusion:Although aerobic exercise is effective in lowering blood TG levels,statins seem to be more efficient,especially in the fasted state.A combination of exercise and statins might reveal a valuable approach to the treatment and prevention of CVD.More studies are required to deter-mine the underlying mechanisms and the possible additive effects of these interventions.

Laura Alvarez-Jimenez;Alfonso Moreno-Caba?as;Miguel Ramirez-Jimenez;Felix Morales-Palomo;Juan F.Ortega;Ricardo Mora-Rodriguez

Exercise Physiology Lab at Toledo,Sports Science Department,University of Castilla-La Mancha,Toledo 45004,Spain

运动与健康科学（英文）

[1]Laura Alvarez-Jimenez;Alfonso Moreno-Caba?as;Miguel Ramirez-Jimenez;Felix Morales-Palomo;Juan F.Ortega;Ricardo Mora-Rodriguez-.Effectiveness of statins vs.exercise on reducing postprandial hypertriglyceridemia in dyslipidemic population:A systematic review and network meta-analysis)[J].运动与健康科学（英文）,2022(05):567-577

dyslipidemic,hypertriglyceride,tins,PPTG

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