典型文献
Alpha-fetoprotein,protein induced by vitamin K absence or antagonist-Ⅱ,lens culinaris agglutinin-reactive fraction of alpha-fetoprotein alone and in combination for early detection of hepatocellular carcinoma from nonalcoholic fatty liver disease:A multicenter analysis
文献摘要：
Background:Current surveillance strategies for hepatocellular carcinoma(HCC)among patients with non-alcoholic fatty liver disease(NAFLD)are insufficient.This study aimed to investigate the diagnostic perfor-mance of alpha-fetoprotein(AFP),protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ),lens culinaris agglutinin-reactive fraction of AFP(AFP-L3),and their combinations in HCC underlying NAFLD patients.Methods:Serologic AFP,AFP-L3,and PIVKA-Ⅱ levels in NAFLD patients with and without HCC were mea-sured.By receiver operating characteristic(ROC)analyses,the area under the curve(AUC),sensitivity,and specificity were obtained to evaluate the diagnostic accuracy of each biomarker and their combinations.Results:This study was conducted on 139 patients with NAFLD-HCC and 345 NAFLD controls.The eleva-tion of these three biomarkers was observed in patients with NAFLD-HCC compared to those in NAFLD controls(all P＜0.001).When they were analyzed individually,PIVKA-Ⅱ showed the best performance in diagnosing any-stage HCC with an AUC of 0.869,followed by AFP(0.763;vs.PIVKA-Ⅱ,P＜0.001)and AFP-L3(0.689;vs.PIVKA-Ⅱ,P＜0.001).When they were analyzed in combination,AFP+PIVKA-Ⅱ yielded the highest AUC(0.906),followed by AFP+PIVKA-Ⅱ+AFP-L3(0.904;vs.AFP+PIVKA-Ⅱ,P=0.086),PIVKA-Ⅱ+AFP-L3(0.881;vs.AFP+PIVKA-Ⅱ,P＜0.001),and AFP+AFP-L3(0.759;vs.AFP+PIVKA-Ⅱ,P＜0.001).Similar findings were obtained in the subgroup with early-stage NAFLD-HCC,as well as the non-cirrhotic subgroup.Conclusions:These data validated the better diagnostic ability of PIVKA-Ⅱ than AFP or AFP-L3 alone for diagnosing any-stage HCC among patients with NAFLD,and the combination of AFP+PIVKA-Ⅱ signifi-cantly improved the diagnostic accuracy of NAFLD-HCC.
文献关键词：
中图分类号：
作者姓名：
Ming-Cheng Guan;Wei Ouyang;Si-Yu Liu;Li-Yang Sun;Wei-Yue Chen;Xiang-Min Tong;Hong Zhu;Tian Yang
作者机构：
Department of Medical Oncology,the First Affiliated Hospital of Soochow University,Suzhou 215006,China;Department of Laboratory,Zhejiang University Lishui Hospital,Lishui 323000,China;Department of Hepatobiliary,Pancreatic and Minimal Invasive Surgery,Zhejiang Provincial People's Hospital,People's Hospital of Hangzhou Medical College,Hangzhou 310014,China;The Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province,Department of Interventional Radiology,Zhejiang University Lishui Hospital,Lishui 323000,China;School of Clinical Medicine,Hangzhou Medical College,Hangzhou 310059,China;Department of Hepatobiliary Surgery,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University(Navy Medical University),Shanghai 200438,China
文献出处：
引用格式：
[1]Ming-Cheng Guan;Wei Ouyang;Si-Yu Liu;Li-Yang Sun;Wei-Yue Chen;Xiang-Min Tong;Hong Zhu;Tian Yang-.Alpha-fetoprotein,protein induced by vitamin K absence or antagonist-Ⅱ,lens culinaris agglutinin-reactive fraction of alpha-fetoprotein alone and in combination for early detection of hepatocellular carcinoma from nonalcoholic fatty liver disease:A multicenter analysis)[J].国际肝胆胰疾病杂志(英文版),2022(06):559-568
A类：
culinaris,Serologic,AFP+PIVKA,+AFP,AFP+AFP
B类：
Alpha,fetoprotein,induced,by,vitamin,absence,antagonist,lens,agglutinin,reactive,fraction,alpha,alone,early,detection,hepatocellular,carcinoma,from,nonalcoholic,fatty,liver,disease,multicenter,analysis,Background,Current,surveillance,strategies,HCC,among,patients,NAFLD,insufficient,This,study,aimed,investigate,diagnostic,L3,their,combinations,underlying,Methods,levels,without,were,mea,sured,By,receiver,operating,characteristic,analyses,area,curve,sensitivity,specificity,obtained,evaluate,accuracy,each,Results,was,conducted,controls,eleva,these,three,biomarkers,observed,compared,those,When,they,analyzed,individually,showed,best,performance,diagnosing,any,stage,followed,yielded,highest,Similar,findings,subgroup,well,cirrhotic,Conclusions,These,data,validated,better,ability,than,signifi,cantly,improved
AB值：
0.384933
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