Objective:Conversion of normal cells to cancer cells is often accompanied by abnormal synthesis of serum enzymes.Both alkaline phosphatase(ALP)and lactate dehydrogenase(LDH)have been reported to have prognostic value in a variety of malignancies.The aim of this study was to investigate the effect of preoperative serum ALP and LDH levels on the prognosis of patients with periampullary carcinoma who underwent pancreatoduodenectomy(PD).Methods:According to the preoperative ALP or LDH values,856 cancer patients receiving PD treatment from January 2001 to January 2019 were divided into high-ALP group and low-ALP group or high-LDH group and low-LDH group.Statistical analysis was carried out to study the differences between the high-ALP and low-ALP groups or the high-LDH and low-LDH groups.Furthermore,the possibility of preoperative ALP or LDH as prognostic factor of periampullary carcinoma was investigated.Results:In both the high-ALP and the high-LDH groups,the prognosis of patients with periampullary carcinoma who underwent PD was worse than that of the low-ALP and low-LDH group.Even through risk factor analysis,it was found that preoperative ALP and LDH could be independent prognostic factor for patients with periampullary carcinoma who underwent PD.Conclusion:Preoperative ALP or LDH is an independent risk factor for periampullary carcinoma.

Chao DANG;Yun-hua DENG;Ren-yi QIN

Department of Pancreatic-Biliary Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Dermatology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

当代医学科学(英文)

[1]Chao DANG;Yun-hua DENG;Ren-yi QIN-.Prognostic Value of ALP and LDH in Periampullary Carcinoma Patients Undergoing Surgery)[J].当代医学科学(英文),2022(01):150-158

Periampullary,pancreatoduodenectomy

Prognostic,Value,ALP,LDH,Carcinoma,Patients,Undergoing,Surgery,Objective,Conversion,cells,cancer,often,accompanied,by,abnormal,synthesis,serum,enzymes,Both,alkaline,phosphatase,lactate,dehydrogenase,have,been,reported,prognostic,variety,malignancies,aim,this,study,was,effect,preoperative,levels,prognosis,patients,periampullary,carcinoma,who,underwent,Methods,According,values,receiving,treatment,from,January,were,divided,into,high,low,Statistical,analysis,carried,out,differences,between,groups,Furthermore,possibility,investigated,Results,In,both,worse,than,that,Even,through,risk,found,could,independent,Conclusion,Preoperative

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