典型文献
Silencing miRNA-324-3p protects against cerebral ischemic injury via regulation of the GATA2/A1R axis
文献摘要：
Previous studies have suggested that miR-324-3p is related to the pathophysiology of cerebral ischemia, but the mechanism underlying this relationship is unclear. In this study, we found that miR-324-3p expression was decreased in patients with acute ischemic stroke and in in vitro and in vivo models of ischemic stroke. miR-324-3p agomir potentiated ischemic brain damage in rats subjected to middle cerebral artery occlusion, as indicated by increased infarct volumes and cell apoptosis rates and greater neurological deficits. In a PC12 cell oxygen-glucose deprivation/reoxygenation model, a miR-324-3p mimic decreased cell viability and expression of the anti-apoptotic protein BCL2 and increased expression of the pro-apoptotic protein BAX and rates of cell apoptosis, whereas treatment with a miR-324-3p inhibitor had the opposite effects. Silencing miR-324-3p increased adenosine A1 receptor (A1R) expression through regulation of GATA binding protein 2 (GATA2). These findings suggest that silencing miR-324-3p reduces ischemic brain damage via the GATA2/A1R axis.
文献关键词：
中图分类号：
作者姓名：
An-Qi Zhang;Lu Wang;Yi-Xiu Wang;Shan-Shan Hong;Yu-Shan Zhong;Ru-Yi Yu;Xin-Lu Wu;Bing-Bing Zhou;Qi-Min Yu;Hai-Feng Fu;Shuang-Dong Chen;Yun-Chang Mo;Qin-Xue Dai;Jun-Lu Wang
作者机构：
Department of Anesthesiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang Province,China;Department of Anesthesiology,Wenzhou Central Hospital,Wenzhou,Zhejiang Province,China
文献出处：
引用格式：
[1]An-Qi Zhang;Lu Wang;Yi-Xiu Wang;Shan-Shan Hong;Yu-Shan Zhong;Ru-Yi Yu;Xin-Lu Wu;Bing-Bing Zhou;Qi-Min Yu;Hai-Feng Fu;Shuang-Dong Chen;Yun-Chang Mo;Qin-Xue Dai;Jun-Lu Wang-.Silencing miRNA-324-3p protects against cerebral ischemic injury via regulation of the GATA2/A1R axis)[J].中国神经再生研究（英文版）,2022(11):2504-2511
A类：
A1R
B类：
Silencing,miRNA,3p,protects,against,cerebral,ischemic,injury,regulation,GATA2,axis,Previous,studies,have,suggested,that,related,pathophysiology,ischemia,but,mechanism,underlying,this,relationship,unclear,In,study,we,found,expression,was,decreased,patients,acute,stroke,vitro,vivo,models,agomir,potentiated,brain,damage,rats,subjected,middle,artery,occlusion,indicated,by,increased,infarct,volumes,cell,apoptosis,rates,greater,neurological,deficits,PC12,glucose,deprivation,reoxygenation,mimic,viability,anti,apoptotic,protein,BCL2,BAX,whereas,treatment,inhibitor,had,opposite,effects,adenosine,receptor,through,binding,These,findings,silencing,reduces
AB值：
0.547921
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