典型文献
Baculoviral inhibitor of apoptosis protein repeat-containing protein 3 delays early Wallerian degeneration after sciatic nerve injury
文献摘要：
Wallerian degeneration is a complex biological process that occurs after nerve injury, and involves nerve degeneration and regeneration.Schwann cells play a crucial role in the cellular and molecular events of Wallerian degeneration of the peripheral nervous system. However, Wallerian degeneration regulating nerve injury and repair remains largely unknown, especially the early response. We have previously reported some key regulators of Wallerian degeneration after sciatic nerve injury. Baculoviral inhibitor of apoptosis protein repeat-containing protein 3 (BIRC3) is an important factor that regulates apoptosis-inhibiting protein. In this study, we established rat models of right sciatic nerve injury. In vitro Schwann cell models were also established and subjected to gene transfection to inhibit and overexpress BIRC3. The data indicated that BIRC3 expression was significantly up-regulated after sciatic nerve injury. Both BIRC3 upregulation and downregulation affected the migration, proliferation and apoptosis of Schwan cells and affected the expression of related factors through activating c-fos and ERK signal pathway. Inhibition of BIRC3 delayed early Wallerian degeneration through inhibiting the apoptosis of Schwann cells after sciatic nerve injury. These findings suggest that BIRC3 plays an important role in peripheral nerve injury repair and regeneration. The study was approved by the Institutional Animal Care and Use Committee of Nantong University, China (approval No. 2019-nsfc004) on March 1, 2019.
文献关键词：
中图分类号：
作者姓名：
Min Cai
作者机构：
Nantong University Medical School,Nantong,Jiangsu Province,China;School of Life Sciences,Jiangsu Key Laboratory of Neuroregeneration,Co-innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China;Department of Hand Surgery,China-Japan Union Hospital of Jilin University,Changchun,Jilin Province,China
文献出处：
引用格式：
[1]Min Cai-.Baculoviral inhibitor of apoptosis protein repeat-containing protein 3 delays early Wallerian degeneration after sciatic nerve injury)[J].中国神经再生研究（英文版）,2022(04):845-853
A类：
Baculoviral,BIRC3,Schwan,Nantong,nsfc004
B类：
inhibitor,apoptosis,protein,repeat,containing,delays,early,Wallerian,degeneration,after,sciatic,nerve,injury,complex,biological,process,that,occurs,involves,regeneration,Schwann,cells,crucial,role,cellular,molecular,events,peripheral,nervous,system,However,regulating,repair,remains,largely,unknown,especially,response,We,have,previously,reported,some,key,regulators,important,regulates,inhibiting,this,study,established,models,right,vitro,were,also,subjected,transfection,overexpress,data,indicated,expression,was,significantly,regulated,Both,upregulation,downregulation,affected,migration,proliferation,related,factors,through,activating,fos,ERK,signal,pathway,Inhibition,delayed,These,findings,suggest,plays,approved,by,Institutional,Animal,Care,Use,Committee,University,China,approval,No,March
AB值：
0.449218
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