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典型文献
Two unique C21-diterpenoid alkaloids from Aconitum carmichaelii
文献摘要:
Two sulfonated diterpenoid alkaloids possessing different but related novel carbon skeletons,named aconidenusulfonine A(1)and 12,16-secoaconidenusulfonine A(2),respectively,were isolated as minor components from an aqueous extract of the lateral roots of Aconitum carmichaelii("Fu Zi").The struc-tures of 1 and 2,representing the first two C21-diterpenoid alkaloids from nature,were determined by analysis of various spectroscopic data and chemical transformation,of which 1 was further proved by single-crystal X-ray diffraction.Especially,1 exhibited dose-depended analgesic activity consistent with the clinical function of Fu Zi.
文献关键词:
作者姓名:
Jingfang Zhang;Xiaoqiang Lei;Yazi Wei;Hui Liu;Qinglan Guo;Tiantai Zhang;Jiangong Shi
作者机构:
State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China
引用格式:
[1]Jingfang Zhang;Xiaoqiang Lei;Yazi Wei;Hui Liu;Qinglan Guo;Tiantai Zhang;Jiangong Shi-.Two unique C21-diterpenoid alkaloids from Aconitum carmichaelii)[J].中国化学快报(英文版),2022(12):5047-5050
A类:
aconidenusulfonine,secoaconidenusulfonine
B类:
Two,unique,C21,diterpenoid,alkaloids,from,Aconitum,carmichaelii,sulfonated,possessing,different,but,related,novel,carbon,skeletons,named,respectively,were,isolated,minor,components,aqueous,extract,lateral,roots,Fu,Zi,struc,tures,representing,first,two,nature,determined,by,analysis,various,spectroscopic,data,chemical,transformation,which,was,further,proved,single,crystal,ray,diffraction,Especially,exhibited,dose,depended,analgesic,activity,consistent,clinical,function
AB值:
0.678943
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