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典型文献
Cross-coupling of 2-methylquinolines and in-situ activated isoquinolines:Construction of 1,2-disubstituted isoquinolinones
文献摘要:
In this study,a method was developed to form C(sp3)-C(sp2)bonds via copper catalyst-promoted cross coupling of 2-methylquinoline and in-situ-activated 3-haloisoquinoline under mild conditions.The multi-component tandem reaction was used to construct new C-N,C=O and C-C bonds in one pot via se-quential functionalization of the N1,C3 and C1 positions of 3-haloisoquinoline.This method can be used to efficiently access 1,2-disubstituted isoquinolinones by the three-component reaction of 3-halogen iso-quinoline,alkyl halide,and 2-methylquinoline.
文献关键词:
作者姓名:
Jianyi Shi;Zheng Zeng;Shengting Xu;Zechun Cai;Yuehua Luo;Yongbo Fan;Zhongzhi Zhu;Tingting Wen;Xiuwen Chen
作者机构:
School of Biotechnology and Health Sciences,Wuyi University,Jiangmen 529020,China;Affiliated Hospital of Guilin Medical University,Guilin 541001,China
引用格式:
[1]Jianyi Shi;Zheng Zeng;Shengting Xu;Zechun Cai;Yuehua Luo;Yongbo Fan;Zhongzhi Zhu;Tingting Wen;Xiuwen Chen-.Cross-coupling of 2-methylquinolines and in-situ activated isoquinolines:Construction of 1,2-disubstituted isoquinolinones)[J].中国化学快报(英文版),2022(11):4874-4877
A类:
methylquinolines,isoquinolines,isoquinolinones,methylquinoline,haloisoquinoline
B类:
Cross,coupling,situ,activated,Construction,disubstituted,In,this,study,method,was,developed,form,sp3,sp2,bonds,via,copper,catalyst,promoted,cross,under,mild,conditions,multi,component,tandem,reaction,used,construct,new,pot,quential,functionalization,N1,C3,C1,positions,This,can,be,efficiently,access,by,three,halogen,alkyl,halide
AB值:
0.540956
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