典型文献
Rapid differentiation of simple saccharides based on cluster ions by paper spray tandem mass spectrometry
文献摘要：
Simple saccharides have a variety of biological functions,but their structural diversity and inherent struc-tural features pose a major challenge for rapid analysis.In this work,we developed a derivative-free and ion mobility-free method for the rapid analysis of monosaccharides and disaccharides using paper spray tandem mass spectrometry.Trimeric cluster ions consisting of saccharide analytes,ligands and transition metal ions are used as precursor ions.We defined the R-value as the ratio of the intensity of the product ion that loses one molecule of ligand over the intensity of the product ion that loses one molecule of saccharide via collision induced dissociation(CID).The species and conformation of simple saccharides can be easily differentiated by calculating this R-value.With the capability of directly analyzing clinical samples using paper spray ionization,our method can be used to rapidly quantify the molar ratio of galactose to glucose in dried plasma samples to aid in the diagnosis of galactosemia.The analytical strat-egy provided herein has good potential to be applied to a wide range of saccharide analysis applications in the future.
文献关键词：
中图分类号：
作者姓名：
Wangmin Hu;Tianyi Li;Yulei Yang;Shanshan Jia;Mei Zhang
作者机构：
School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China;National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China
文献出处：
引用格式：
[1]Wangmin Hu;Tianyi Li;Yulei Yang;Shanshan Jia;Mei Zhang-.Rapid differentiation of simple saccharides based on cluster ions by paper spray tandem mass spectrometry)[J].中国化学快报（英文版）,2022(11):4808-4816
A类：
disaccharides,Trimeric,galactosemia
B类：
Rapid,differentiation,simple,cluster,by,paper,spray,tandem,mass,spectrometry,Simple,have,variety,biological,functions,but,their,structural,diversity,inherent,features,pose,major,challenge,analysis,In,this,work,we,developed,derivative,free,mobility,method,monosaccharides,using,consisting,analytes,ligands,transition,metal,are,used,precursor,We,defined,value,ratio,intensity,product,that,loses,one,molecule,over,via,collision,induced,dissociation,CID,species,conformation,can,be,easily,differentiated,calculating,With,capability,directly,analyzing,clinical,samples,ionization,our,rapidly,quantify,molar,glucose,dried,plasma,aid,diagnosis,analytical,strat,egy,provided,herein,has,good,potential,applied,wide,range,applications,future
AB值：
0.548841
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